New drugs for the treatment of hypertension

Giuseppe Mancia, Maria Luisa Stella, Guido Grassi

Research output: Contribution to journalArticlepeer-review


Despite the many outstanding favorable results achieved in the treatment of hypertension, several unmet goals of antihypertensive therapy remain, such as better blood pressure control, greater protection against the organ damage associated with hypertension, better tolerability, and ultimately a more effective prevention of cardiovascular disease. These unmet goals are the reasons why new antihypertensive drugs are synthesized and tested in the clinical practice. This paper briefly mentions the goals of new antihypertensive agents and examines the main pharmacological and clinical features of new classes of antihypertensive drugs, such as angiotensin II receptor blockers, central agents, vasopeptidase inhibitors, and endothelin antagonists. The results of experimental and clinical studies with these new drugs are reviewed, emphasizing some advantages and potential disadvantages of these drugs compared with traditional antihypertensive drugs.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalCurrent Opinion in Cardiology
Issue number5
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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