Nuovi indicatori di effetto

Translated title of the contribution: New effect biomarkers

G. De Palma, M. Corradi, A. Mutti, A. Baccarelli, A. Pesatori, P. A. Bertazzi

Research output: Contribution to journalArticlepeer-review


The major research goals for researchers developing biomarkers of effect are the development and validation of biomarkers that permit the prediction of the risk of disease in individuals and groups. One important objective is to prevent human cancer. This article reviews the most recent analytical methodologies, validation studies and field trials together with auditing and quality assessment of the necessary data based on scientific grounds. Consideration is given to new developments in the relatively young field of toxicogenomics, possibly leading to the identification of early changes that may lead to both cancer and non-cancer end points. Although the creation and development of reliable databases integrating information from genomic and proteomic research programmes should offer a contribution to the prediction of risks and prevention of diseases related to chemical exposure, the most promising future application of these technologies lies in the molecular diagnosis of diseases whose nosography will probably be redefined.

Translated title of the contributionNew effect biomarkers
Original languageItalian
Pages (from-to)302-310
Number of pages9
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Issue number4
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation


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