New emerging diseases or syndromes in dermatopathology with impact on clinical management

Elisa Cinotti, Franco Rongioletti

Research output: Contribution to journalArticlepeer-review


New cutaneous emerging disorders have been recently defined, in terms of both clinical and histopathological features, with impact on clinical management. Aquagenic palmoplantar keratoderma is a hyperwrinkling of palms and/or soles on exposure to water, which may be a sign of cystic fibrosis or of the carrier status of this disease. Pretibial mucinosis is not only associated with Graves' disease (pretibial myxedema), but can be a consequence of lower leg edema. In particular, it has been observed in obese patients with lymphedema and in venous insufficiency. Circumscribed palmoplantar hypokeratosis should not be underestimated because it might have a potential of malignant transformation. An extensive skin erythematous patch of the chest, with mucinous angiomatosis at the histopathological examination, is an early sign of an underlying plasmacytoma (adenopathy and extensive skin patch overlying a plasmacytoma syndrome). Eosinophilic annular erythema is a clinical subset of Well's syndrome presenting with an annular or figurate pattern.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalExpert Review of Dermatology
Issue number1
Publication statusPublished - Feb 2012


  • Aquagenic palmoplantar keratoderma
  • Circumscribed palmoplantar hypokeratosis
  • Eosinophilic annular erythema
  • Obesity-associated lymphedematous mucinosis

ASJC Scopus subject areas

  • Dermatology


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