New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea

A. Malesci, A. Mariani, G. Mezzi, P. Bocchia, M. Basilico

Research output: Contribution to journalArticlepeer-review


We studied a new enteric-coated pancreatic extract with very high lipase content in 12 patients with Steatorrhea due to chronic pancreatitis. Fecal fat was measured under standard dietary conditions (100 g lipid/day) with no enzyme supplementation and during treatment with 75,000, 150,000, or 225,000 IU of lipase per day. The median fecal fat output (g/day) was significantly (p <0.005) lower after each increase in dosage: basal, 20.5 (range, 10.3–92.2); 3 cps/day at meals, 13.3 (6.4–38.2); 6 cps/day, 9.9 (4.8–31.4); 9 cps/day, 7.3 (2.6–17.3). For the five patients with a basal fecal fat output of <15 g/day, Steatorrhea was totally corrected by 3 cps a day. Of the seven patients with more severe Steatorrhea, the fecal fat output of only two was not normalized with the highest dose of 9 cps/day: for one it was reduced to 13.3 g/day from a basal of 92.2 g/day and for the other to 17.3 g/day from 25.4 g/day. This pilot study demonstrates that the tested pancreatic extract very effectively corrects pancreatic Steatorrhea in a simple low-dose regimen. Good compliance can be expected.

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalJournal of Clinical Gastroenterology
Issue number1
Publication statusPublished - 1994


  • Chronic pancreatitis
  • Lipase
  • Pancreatic extract
  • Pancreatic Steatorrhea

ASJC Scopus subject areas

  • Gastroenterology


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