Abstract
The evidence that some classes of antihypertensive drugs, particularly the calcium antagonists and the ACE-inhibitors, have an antiatherogenic action, at least partly independent of the antihypertensive one, is largely based on a series of experimental studies. The few clinical studies completed so far have been performed on coronary lesions of patients with ischemic heart disease. However, the issue of the anti-atherosclerotic action of antihypertensive agents can best be explored in hypertensive patients. Ultrasound quantitative evaluation of the development of asymptomatic carotid artery atherosclerotic lesions can now be used as end point for trials comparing the efficacy of different antihypertensive compounds. Stimulated by the design of the MIDAS trial (Multicenter Isradipine/Diuretic Atherosclerosis Study), based in USA, several trials have been planned and are being conducted in Europe.
| Original language | English |
|---|---|
| Pages (from-to) | 115-118 |
| Number of pages | 4 |
| Journal | The International Journal of Cardiac Imaging |
| Volume | 11 |
| Issue number | 2 Supplement |
| DOIs | |
| Publication status | Published - Jun 1995 |
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ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
New European studies on atherosclerosis in hypertension. / Zanchetti, Alberto.
In: The International Journal of Cardiac Imaging, Vol. 11, No. 2 Supplement, 06.1995, p. 115-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New European studies on atherosclerosis in hypertension
AU - Zanchetti, Alberto
PY - 1995/6
Y1 - 1995/6
N2 - The evidence that some classes of antihypertensive drugs, particularly the calcium antagonists and the ACE-inhibitors, have an antiatherogenic action, at least partly independent of the antihypertensive one, is largely based on a series of experimental studies. The few clinical studies completed so far have been performed on coronary lesions of patients with ischemic heart disease. However, the issue of the anti-atherosclerotic action of antihypertensive agents can best be explored in hypertensive patients. Ultrasound quantitative evaluation of the development of asymptomatic carotid artery atherosclerotic lesions can now be used as end point for trials comparing the efficacy of different antihypertensive compounds. Stimulated by the design of the MIDAS trial (Multicenter Isradipine/Diuretic Atherosclerosis Study), based in USA, several trials have been planned and are being conducted in Europe.
AB - The evidence that some classes of antihypertensive drugs, particularly the calcium antagonists and the ACE-inhibitors, have an antiatherogenic action, at least partly independent of the antihypertensive one, is largely based on a series of experimental studies. The few clinical studies completed so far have been performed on coronary lesions of patients with ischemic heart disease. However, the issue of the anti-atherosclerotic action of antihypertensive agents can best be explored in hypertensive patients. Ultrasound quantitative evaluation of the development of asymptomatic carotid artery atherosclerotic lesions can now be used as end point for trials comparing the efficacy of different antihypertensive compounds. Stimulated by the design of the MIDAS trial (Multicenter Isradipine/Diuretic Atherosclerosis Study), based in USA, several trials have been planned and are being conducted in Europe.
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UR - http://www.scopus.com/inward/citedby.url?scp=34249756274&partnerID=8YFLogxK
U2 - 10.1007/BF01419824
DO - 10.1007/BF01419824
M3 - Article
VL - 11
SP - 115
EP - 118
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 2 Supplement
ER -