New Fields of Application of the Sentinel Lymph Node Biopsy in the Pathologic Staging of Solid Neoplasms: Review of Literature and Surgical Perspectives

Marco Gipponi, Nicola Solari, Franco C. Di Somma, Sergio Bertoglio, Ferdinando Cafiero

Research output: Contribution to journalArticlepeer-review

Abstract

Sentinel lymph node (sN) biopsy has gained special attention among surgical and medical oncologists as it represents an accepted technique for detecting occult nodal disease in regional lymph nodes of patients with melanoma and breast cancer. The histopathologic examination of the sN may well predict regional lymph node status in order to define the most suitable loco-regional and systemic treatment. Recently, this technique has also been applied to other solid tumor types such as gynecologic and urologic malignancies, squamous head and neck cancer, thyroid cancer, non-small-cell lung cancer, Merkel cell carcinoma, and gastric cancer. The aim of this literature review is to define the rationale of sN biopsy in these tumor sites, the most effective procedure for sN detection, and the accuracy of the sN in predicting regional nodal status, as well as the surgical perspectives of sN biopsy application.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalJournal of Surgical Oncology
Volume85
Issue number3
DOIs
Publication statusPublished - Mar 1 2004

Keywords

  • Gynecologic cancer
  • Sentinel lymph node biopsy
  • Staging
  • Urologic cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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