TY - JOUR
T1 - New frontiers for astrocytic tumours
AU - Nano, Rosanna
AU - Lascialfari, Alessandro
AU - Corti, Maurizio
AU - Paolini, Alessandro
AU - Pasi, Francesca
AU - Corbella, Franco
AU - Di Liberto, Riccardo
PY - 2012/7
Y1 - 2012/7
N2 - Glioblastoma multiforme, the most common type of primary brain tumour, remains an unsolved clinical problem. A great deal of work has been done in an effort to understand the biology and genetics of glioblastoma multiforme, but clinically effective treatments remain elusive. It is well known that malignant gliomas develop resistance to chemo- and radiotherapy. In this review we evaluated the literature data regarding therapeutic progress for the treatment of astrocytic tumours, focusing our attention on new frontiers for glioblastoma. The research studies performed in in vitro and in vivo models show that the application of hyperthermia using magnetic nanoparticles is safe and could be a promising tool in the treatment of glioblastoma patients. Our efforts are focused towards new fields of research, for example nanomedicine and the study of the uptake and cytotoxic effects of magnetic nanoparticles. The improvement of the quality of life of patients, by increasing their survival rate is the best result to be pursued, since these tumours are considered as ineradicable.
AB - Glioblastoma multiforme, the most common type of primary brain tumour, remains an unsolved clinical problem. A great deal of work has been done in an effort to understand the biology and genetics of glioblastoma multiforme, but clinically effective treatments remain elusive. It is well known that malignant gliomas develop resistance to chemo- and radiotherapy. In this review we evaluated the literature data regarding therapeutic progress for the treatment of astrocytic tumours, focusing our attention on new frontiers for glioblastoma. The research studies performed in in vitro and in vivo models show that the application of hyperthermia using magnetic nanoparticles is safe and could be a promising tool in the treatment of glioblastoma patients. Our efforts are focused towards new fields of research, for example nanomedicine and the study of the uptake and cytotoxic effects of magnetic nanoparticles. The improvement of the quality of life of patients, by increasing their survival rate is the best result to be pursued, since these tumours are considered as ineradicable.
KW - Astrocytic tumours
KW - Glioblastoma multiforme
KW - Magnetic nanoparticles
KW - Review
KW - Thermotherapy
UR - http://www.scopus.com/inward/record.url?scp=84865679775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865679775&partnerID=8YFLogxK
M3 - Article
C2 - 22753735
AN - SCOPUS:84865679775
VL - 32
SP - 2755
EP - 2758
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 7
ER -