New frontiers for astrocytic tumours

Rosanna Nano, Alessandro Lascialfari, Maurizio Corti, Alessandro Paolini, Francesca Pasi, Franco Corbella, Riccardo Di Liberto

Research output: Contribution to journalArticlepeer-review

Abstract

Glioblastoma multiforme, the most common type of primary brain tumour, remains an unsolved clinical problem. A great deal of work has been done in an effort to understand the biology and genetics of glioblastoma multiforme, but clinically effective treatments remain elusive. It is well known that malignant gliomas develop resistance to chemo- and radiotherapy. In this review we evaluated the literature data regarding therapeutic progress for the treatment of astrocytic tumours, focusing our attention on new frontiers for glioblastoma. The research studies performed in in vitro and in vivo models show that the application of hyperthermia using magnetic nanoparticles is safe and could be a promising tool in the treatment of glioblastoma patients. Our efforts are focused towards new fields of research, for example nanomedicine and the study of the uptake and cytotoxic effects of magnetic nanoparticles. The improvement of the quality of life of patients, by increasing their survival rate is the best result to be pursued, since these tumours are considered as ineradicable.

Original languageEnglish
Pages (from-to)2755-2758
Number of pages4
JournalAnticancer Research
Volume32
Issue number7
Publication statusPublished - Jul 2012

Keywords

  • Astrocytic tumours
  • Glioblastoma multiforme
  • Magnetic nanoparticles
  • Review
  • Thermotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'New frontiers for astrocytic tumours'. Together they form a unique fingerprint.

Cite this