New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication

M. S. De Mitri, R. Cassini, G. Morsica, S. Bagaglio, M. Zoli, M. Bernardi

Research output: Contribution to journalArticle

Abstract

Background. Experimental hepatitis C virus infection in chimpanzees has shown that natural hepatitis C virus infection does not induce protective immunity and reinfection can occur in seroconverted animals. Aim. To study the clinical, virological and histological outcome of a new infection sustained by a different hepatitis C virus strain after a primary infection with eradication of the original virus. Patients and methods. A young Italian man with chronic hepatitis C virus type 4 hepatitis was treated with Interferon therapy and achieved a sustained biochemical and virological response. After long follow-up, an asymptomatic flare-up of alanine transaminase occurred. This alanine transaminase increase was associated with serum hepatitis C virus RNA positivity and a low viral load, and the infecting hepatitis C virus genotype was type 3. The clinical and virological course of this new infection is described. Results and Conclusions. This report shows that there is no protective immunity against hepatitis C virus type 3 after infection by hepatitis C virus type 4 strain.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalDigestive and Liver Disease
Volume33
Issue number7
Publication statusPublished - 2001

Fingerprint

Hepacivirus
Infection
Virus Diseases
Alanine Transaminase
Immunity
Pan troglodytes
Chronic Hepatitis C
Viral Load
Interferons
Hepatitis
Genotype
RNA
Viruses
Serum

Keywords

  • Chronic hepatitis
  • Genotype
  • Hepatitis C virus
  • Interferon

ASJC Scopus subject areas

  • Gastroenterology

Cite this

New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication. / De Mitri, M. S.; Cassini, R.; Morsica, G.; Bagaglio, S.; Zoli, M.; Bernardi, M.

In: Digestive and Liver Disease, Vol. 33, No. 7, 2001, p. 591-594.

Research output: Contribution to journalArticle

De Mitri, MS, Cassini, R, Morsica, G, Bagaglio, S, Zoli, M & Bernardi, M 2001, 'New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication', Digestive and Liver Disease, vol. 33, no. 7, pp. 591-594.
De Mitri, M. S. ; Cassini, R. ; Morsica, G. ; Bagaglio, S. ; Zoli, M. ; Bernardi, M. / New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication. In: Digestive and Liver Disease. 2001 ; Vol. 33, No. 7. pp. 591-594.
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