Abstract
Background. Experimental hepatitis C virus infection in chimpanzees has shown that natural hepatitis C virus infection does not induce protective immunity and reinfection can occur in seroconverted animals. Aim. To study the clinical, virological and histological outcome of a new infection sustained by a different hepatitis C virus strain after a primary infection with eradication of the original virus. Patients and methods. A young Italian man with chronic hepatitis C virus type 4 hepatitis was treated with Interferon therapy and achieved a sustained biochemical and virological response. After long follow-up, an asymptomatic flare-up of alanine transaminase occurred. This alanine transaminase increase was associated with serum hepatitis C virus RNA positivity and a low viral load, and the infecting hepatitis C virus genotype was type 3. The clinical and virological course of this new infection is described. Results and Conclusions. This report shows that there is no protective immunity against hepatitis C virus type 3 after infection by hepatitis C virus type 4 strain.
| Original language | English |
|---|---|
| Pages (from-to) | 591-594 |
| Number of pages | 4 |
| Journal | Digestive and Liver Disease |
| Volume | 33 |
| Issue number | 7 |
| Publication status | Published - 2001 |
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Keywords
- Chronic hepatitis
- Genotype
- Hepatitis C virus
- Interferon
ASJC Scopus subject areas
- Gastroenterology
Cite this
New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication. / De Mitri, M. S.; Cassini, R.; Morsica, G.; Bagaglio, S.; Zoli, M.; Bernardi, M.
In: Digestive and Liver Disease, Vol. 33, No. 7, 2001, p. 591-594.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication
AU - De Mitri, M. S.
AU - Cassini, R.
AU - Morsica, G.
AU - Bagaglio, S.
AU - Zoli, M.
AU - Bernardi, M.
PY - 2001
Y1 - 2001
N2 - Background. Experimental hepatitis C virus infection in chimpanzees has shown that natural hepatitis C virus infection does not induce protective immunity and reinfection can occur in seroconverted animals. Aim. To study the clinical, virological and histological outcome of a new infection sustained by a different hepatitis C virus strain after a primary infection with eradication of the original virus. Patients and methods. A young Italian man with chronic hepatitis C virus type 4 hepatitis was treated with Interferon therapy and achieved a sustained biochemical and virological response. After long follow-up, an asymptomatic flare-up of alanine transaminase occurred. This alanine transaminase increase was associated with serum hepatitis C virus RNA positivity and a low viral load, and the infecting hepatitis C virus genotype was type 3. The clinical and virological course of this new infection is described. Results and Conclusions. This report shows that there is no protective immunity against hepatitis C virus type 3 after infection by hepatitis C virus type 4 strain.
AB - Background. Experimental hepatitis C virus infection in chimpanzees has shown that natural hepatitis C virus infection does not induce protective immunity and reinfection can occur in seroconverted animals. Aim. To study the clinical, virological and histological outcome of a new infection sustained by a different hepatitis C virus strain after a primary infection with eradication of the original virus. Patients and methods. A young Italian man with chronic hepatitis C virus type 4 hepatitis was treated with Interferon therapy and achieved a sustained biochemical and virological response. After long follow-up, an asymptomatic flare-up of alanine transaminase occurred. This alanine transaminase increase was associated with serum hepatitis C virus RNA positivity and a low viral load, and the infecting hepatitis C virus genotype was type 3. The clinical and virological course of this new infection is described. Results and Conclusions. This report shows that there is no protective immunity against hepatitis C virus type 3 after infection by hepatitis C virus type 4 strain.
KW - Chronic hepatitis
KW - Genotype
KW - Hepatitis C virus
KW - Interferon
UR - http://www.scopus.com/inward/record.url?scp=0034782867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034782867&partnerID=8YFLogxK
M3 - Article
C2 - 11816550
AN - SCOPUS:0034782867
VL - 33
SP - 591
EP - 594
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 7
ER -