New insights in airway remodeling

D. Descalzi, C. Folli, F. Scordamaglia, A. M. Riccio, C. Gamalero, M. Barbieri, B. Azzarone, G. Walter Canonica

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Airway remodeling is an alteration in the size, mass, or number of tissue structural components that occurs during growth or in response to injury and/or inflammation. The primary inflammatory lesion consists of accumulation of CD4+ T-helper cell type 2 (Th2) lymphocytes and eosinophils in the airway mucosa. A first step in the control of the aberrant responses in airway diseases could be to identify in CD40-CD40L interaction one of the possible mechanism by which epithelial cells promote and sustain airway inflammation [10]. Methods/Data base: A review of the literature and own studies. Results/Conclusions: The transformation of fibroblasts into myofibroblasts is a crucial step of airway remodeling and one of the principal aims of future studies might be its downregulation as early as possible. The real impact of upper airway remodeling still remains unclear and further investigations are needed.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalAllergy and Clinical Immunology International
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Airway remodeling
  • Asthma
  • Corticosteroids
  • Fibroblasts
  • Statins

ASJC Scopus subject areas

  • Immunology and Allergy

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