Nuovi approfondimenti nella ricerca su l'ateroslerosi

LOX-1, un primo attore nelle malattie cardiovascolari

Translated title of the contribution: New insights in atherosclerosis research: LOX-1, leading actor of cardiovascular diseases

Giuseppe Novelli, R. Mango, L. Vecchione, E. Mariotti, P. Borgiani, J. L. Mehta, F. Romeo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The OLR1 gene encodes a cell-surface endocytosis receptor (LOX-1) for oxidized low density lipoprotein (OxLDL). LDL is oxidized in vascular endothelial cells to a highly injurious product that results in endothelial cell injury, which is implicated in the development of atherosclerosis. Vascular endothelial cells also internalize and degrade oxLDL though the OLR1 receptor. This receptor is upregulated by ox-LDL itself and by angiotensin II, endothelin, cytokines, and shear stress, important factors of atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Two independent studies have demonstrated genetic association between polymorphisms in the OLR1 gene and myocardial infarction. Based on genetic and functional studies we propose LOX-1 as a novel biomarker and target in cardiovascular disease diagnosis and prevention.

Original languageItalian
Pages (from-to)239-248
Number of pages10
JournalClinica Terapeutica
Volume158
Issue number3
Publication statusPublished - May 2007

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Atherosclerosis
Cardiovascular Diseases
Endothelial Cells
Research
Endothelins
Cell Surface Receptors
Endocytosis
Angiotensin II
Genes
Arteries
Biomarkers
Myocardial Infarction
Cytokines
oxidized low density lipoprotein
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Novelli, G., Mango, R., Vecchione, L., Mariotti, E., Borgiani, P., Mehta, J. L., & Romeo, F. (2007). Nuovi approfondimenti nella ricerca su l'ateroslerosi: LOX-1, un primo attore nelle malattie cardiovascolari. Clinica Terapeutica, 158(3), 239-248.

Nuovi approfondimenti nella ricerca su l'ateroslerosi : LOX-1, un primo attore nelle malattie cardiovascolari. / Novelli, Giuseppe; Mango, R.; Vecchione, L.; Mariotti, E.; Borgiani, P.; Mehta, J. L.; Romeo, F.

In: Clinica Terapeutica, Vol. 158, No. 3, 05.2007, p. 239-248.

Research output: Contribution to journalArticle

Novelli, G, Mango, R, Vecchione, L, Mariotti, E, Borgiani, P, Mehta, JL & Romeo, F 2007, 'Nuovi approfondimenti nella ricerca su l'ateroslerosi: LOX-1, un primo attore nelle malattie cardiovascolari', Clinica Terapeutica, vol. 158, no. 3, pp. 239-248.
Novelli G, Mango R, Vecchione L, Mariotti E, Borgiani P, Mehta JL et al. Nuovi approfondimenti nella ricerca su l'ateroslerosi: LOX-1, un primo attore nelle malattie cardiovascolari. Clinica Terapeutica. 2007 May;158(3):239-248.
Novelli, Giuseppe ; Mango, R. ; Vecchione, L. ; Mariotti, E. ; Borgiani, P. ; Mehta, J. L. ; Romeo, F. / Nuovi approfondimenti nella ricerca su l'ateroslerosi : LOX-1, un primo attore nelle malattie cardiovascolari. In: Clinica Terapeutica. 2007 ; Vol. 158, No. 3. pp. 239-248.
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