Abstract
Mitochondria are now recognized as one of the main intracellular calcium-storing organelles which play a key role in the intracellular calcium signalling. Indeed, besides performing oxidative phosphorylation, mitochondria are able to sense and shape calcium (Ca2+) transients, thus controlling cytosolic Ca2+ signals and Ca2+-dependent protein activity. It has been well established for many years that mitochondria have a huge capacity to accumulate calcium. While the physiological significance of this pathway was hotly debated until relatively recently, it is now clear that the ability of mitochondria in calcium handling is a ubiquitous phenomenon described in every cell system in which the issue has been addressed. In this chapter, we will review the molecular mechanisms involved in the regulation of mitochondrial calcium cycling in physiological conditions with particular regard to the role played by the mitochondrial Na+/Ca2+ exchanger.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Pages | 203-209 |
| Number of pages | 7 |
| Volume | 961 |
| DOIs | |
| Publication status | Published - 2013 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 961 |
| ISSN (Print) | 00652598 |
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Keywords
- AKAP
- Calcium
- MCU
- Mitochondria
- NCX3
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
New insights in mitochondrial calcium handling by sodium/calcium exchanger. / Scorziello, Antonella; Savoia, Claudia; Secondo, Agnese; Boscia, Francesca; Sisalli, Maria Josè; Esposito, Alba; Carlucci, Annalisa; Molinaro, Pasquale; Lignitto, Luca; Di Renzo, Gianfranco; Feliciello, Antonio; Annunziato, Lucio.
Advances in Experimental Medicine and Biology. Vol. 961 2013. p. 203-209 (Advances in Experimental Medicine and Biology; Vol. 961).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - New insights in mitochondrial calcium handling by sodium/calcium exchanger
AU - Scorziello, Antonella
AU - Savoia, Claudia
AU - Secondo, Agnese
AU - Boscia, Francesca
AU - Sisalli, Maria Josè
AU - Esposito, Alba
AU - Carlucci, Annalisa
AU - Molinaro, Pasquale
AU - Lignitto, Luca
AU - Di Renzo, Gianfranco
AU - Feliciello, Antonio
AU - Annunziato, Lucio
PY - 2013
Y1 - 2013
N2 - Mitochondria are now recognized as one of the main intracellular calcium-storing organelles which play a key role in the intracellular calcium signalling. Indeed, besides performing oxidative phosphorylation, mitochondria are able to sense and shape calcium (Ca2+) transients, thus controlling cytosolic Ca2+ signals and Ca2+-dependent protein activity. It has been well established for many years that mitochondria have a huge capacity to accumulate calcium. While the physiological significance of this pathway was hotly debated until relatively recently, it is now clear that the ability of mitochondria in calcium handling is a ubiquitous phenomenon described in every cell system in which the issue has been addressed. In this chapter, we will review the molecular mechanisms involved in the regulation of mitochondrial calcium cycling in physiological conditions with particular regard to the role played by the mitochondrial Na+/Ca2+ exchanger.
AB - Mitochondria are now recognized as one of the main intracellular calcium-storing organelles which play a key role in the intracellular calcium signalling. Indeed, besides performing oxidative phosphorylation, mitochondria are able to sense and shape calcium (Ca2+) transients, thus controlling cytosolic Ca2+ signals and Ca2+-dependent protein activity. It has been well established for many years that mitochondria have a huge capacity to accumulate calcium. While the physiological significance of this pathway was hotly debated until relatively recently, it is now clear that the ability of mitochondria in calcium handling is a ubiquitous phenomenon described in every cell system in which the issue has been addressed. In this chapter, we will review the molecular mechanisms involved in the regulation of mitochondrial calcium cycling in physiological conditions with particular regard to the role played by the mitochondrial Na+/Ca2+ exchanger.
KW - AKAP
KW - Calcium
KW - MCU
KW - Mitochondria
KW - NCX3
UR - http://www.scopus.com/inward/record.url?scp=84873592125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873592125&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-4756-6-17
DO - 10.1007/978-1-4614-4756-6-17
M3 - Conference contribution
C2 - 23224881
AN - SCOPUS:84873592125
SN - 9781461447559
VL - 961
T3 - Advances in Experimental Medicine and Biology
SP - 203
EP - 209
BT - Advances in Experimental Medicine and Biology
ER -