Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario.

Translated title of the contribution: New insights in the pathogenesis of secondary hyperparathyroidism

M. Cozzolino, A. Butti, G. Chiarelli, L. Rocca-Rey, A. Bellasi, A. Galassi, M. Gallieni, D. Brancaccio

Research output: Contribution to journalArticlepeer-review


Parathyroid gland growth is a major cause of secondary hyperparathyroidism in renal failure. It is well known that high serum phosphate levels, low serum calcium levels and vitamin D deficiency are the three promoters of parathyroid hyperplasia in renal failure. Recent studies have investigated in depth the potential role of growth factors (transforming growth factor alpha) and their receptors (epidermal growth factor receptor) in the pathogenesis of parathyroid cell hyperplasia in chronic renal failure. The identification of molecular mechanisms involved in calcium, phosphate and vitamin D manipulations in an experimental renal failure model could help design more effective therapy for secondary hyperparathyroidism in uremic patients.

Translated title of the contributionNew insights in the pathogenesis of secondary hyperparathyroidism
Original languageItalian
Pages (from-to)329-336
Number of pages8
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Issue number4
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Nephrology


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