Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario.

Translated title of the contribution: New insights in the pathogenesis of secondary hyperparathyroidism

M. Cozzolino, A. Butti, G. Chiarelli, L. Rocca-Rey, A. Bellasi, A. Galassi, M. Gallieni, D. Brancaccio

Research output: Contribution to journalArticle

Abstract

Parathyroid gland growth is a major cause of secondary hyperparathyroidism in renal failure. It is well known that high serum phosphate levels, low serum calcium levels and vitamin D deficiency are the three promoters of parathyroid hyperplasia in renal failure. Recent studies have investigated in depth the potential role of growth factors (transforming growth factor alpha) and their receptors (epidermal growth factor receptor) in the pathogenesis of parathyroid cell hyperplasia in chronic renal failure. The identification of molecular mechanisms involved in calcium, phosphate and vitamin D manipulations in an experimental renal failure model could help design more effective therapy for secondary hyperparathyroidism in uremic patients.

Original languageItalian
Pages (from-to)329-336
Number of pages8
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume22
Issue number4
Publication statusPublished - Jul 2005

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Secondary Hyperparathyroidism
Renal Insufficiency
Epidermal Growth Factor Receptor
Hyperplasia
Parathyroid Glands
Vitamin D Deficiency
Serum
Vitamin D
Chronic Kidney Failure
Intercellular Signaling Peptides and Proteins
Phosphates
Calcium
Growth
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario. / Cozzolino, M.; Butti, A.; Chiarelli, G.; Rocca-Rey, L.; Bellasi, A.; Galassi, A.; Gallieni, M.; Brancaccio, D.

In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Vol. 22, No. 4, 07.2005, p. 329-336.

Research output: Contribution to journalArticle

Cozzolino, M, Butti, A, Chiarelli, G, Rocca-Rey, L, Bellasi, A, Galassi, A, Gallieni, M & Brancaccio, D 2005, 'Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario.', Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, vol. 22, no. 4, pp. 329-336.
Cozzolino, M. ; Butti, A. ; Chiarelli, G. ; Rocca-Rey, L. ; Bellasi, A. ; Galassi, A. ; Gallieni, M. ; Brancaccio, D. / Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario. In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia. 2005 ; Vol. 22, No. 4. pp. 329-336.
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