TY - JOUR
T1 - New insights into endometrial cancer
AU - Paleari, Laura
AU - Pesce, Silvia
AU - Rutigliani, Mariangela
AU - Greppi, Marco
AU - Obino, Valentina
AU - Gorlero, Franco
AU - Vellone, Valerio Gaetano
AU - Marcenaro, Emanuela
N1 - Funding Information:
This work was supported by grants from Compagnia di San Paolo (2019.866) to E.M., S.P.; Fondazione Associazione Italiana per la Ricerca sul Cancro (AIRC 5 ? 1000-21147) to E.M., S.P., L.P.; ROCHE 2017 to S.P., E.M. M.G. was supported by a FIRC-AIRC fellowship for Italy.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Here we highlight insights for EC management from diagnosis to a desirable trend of personalized treatment.
AB - EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Here we highlight insights for EC management from diagnosis to a desirable trend of personalized treatment.
KW - Endometrial cancer
KW - Hormone therapy
KW - Immune checkpoint inhibitors
KW - Molecular classification
KW - Natural Killer cells
KW - Steroid receptors
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U2 - 10.3390/cancers13071496
DO - 10.3390/cancers13071496
M3 - Review article
AN - SCOPUS:85102869655
VL - 13
SP - 1496
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 7
ER -