New insights into nevogenesis: In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy

Giovanni Pellacani, Alon Scope, Barbara Ferrari, Gaia Pupelli, Sara Bassoli, Caterina Longo, Anna Maria Cesinaro, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, Josep Malvehy, Ashfaq A. Marghoob, Susana Puig, Stefania Seidenari, H. Peter Soyer, Iris Zalaudek

Research output: Contribution to journalArticle

Abstract

Background: Development of melanocytic nevi is a complex process. Objective: The aim of the study was to characterize the in vivo confocal microscopy patterns and histopathologic correlates of melanocytic nevi. In addition, for the first time, confocal follow-up of characteristic nevi was performed documenting histologic changes in nevi. Methods: For the correlation study, 33 melanocytic nevi showing characteristic dermatoscopic patterns were studied by confocal microscopy. For the follow-up study 20 nevi were monitored for 12 to 18 months. Results: Reticular nevi showed two different confocal patterns, ringed and meshwork, mostly corresponding to lentiginous and nested junctional patterns, respectively. Globular nevi presented large junctional clusters, whereas cobblestone nevi were constituted by dermal dense melanocytic clusters. Homogeneous nevi did not show distinctive confocal and histopathologic findings. Nevi with a rim of globules presented a meshwork pattern with junctional clusters at the periphery. At the confocal follow-up study all lesions showed limited dynamic changes resulting in stable dermatoscopic and confocal patterns, but 3 globular nevi with junctional nests at baseline evolved into reticular-meshwork pattern nevi with peripheral rim of globules-junctional nests. Limitations: Longer confocal follow-up of more melanocytic nevi is required to confirm this theory and to validate our preliminary findings. Conclusions: A model explaining the nevus classification and patterns of evolution of nevi observed in the study was proposed.

Original languageEnglish
Pages (from-to)1001-1013
Number of pages13
JournalJournal of the American Academy of Dermatology
Volume61
Issue number6
DOIs
Publication statusPublished - Dec 2009

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Pigmented Nevus
Nevus
Confocal Microscopy

Keywords

  • follow-up
  • histopathology
  • nevogenesis
  • nevus evolution
  • reflectance confocal microscopy

ASJC Scopus subject areas

  • Dermatology

Cite this

New insights into nevogenesis : In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy. / Pellacani, Giovanni; Scope, Alon; Ferrari, Barbara; Pupelli, Gaia; Bassoli, Sara; Longo, Caterina; Cesinaro, Anna Maria; Argenziano, Giuseppe; Hofmann-Wellenhof, Rainer; Malvehy, Josep; Marghoob, Ashfaq A.; Puig, Susana; Seidenari, Stefania; Soyer, H. Peter; Zalaudek, Iris.

In: Journal of the American Academy of Dermatology, Vol. 61, No. 6, 12.2009, p. 1001-1013.

Research output: Contribution to journalArticle

Pellacani, G, Scope, A, Ferrari, B, Pupelli, G, Bassoli, S, Longo, C, Cesinaro, AM, Argenziano, G, Hofmann-Wellenhof, R, Malvehy, J, Marghoob, AA, Puig, S, Seidenari, S, Soyer, HP & Zalaudek, I 2009, 'New insights into nevogenesis: In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy', Journal of the American Academy of Dermatology, vol. 61, no. 6, pp. 1001-1013. https://doi.org/10.1016/j.jaad.2009.04.018
Pellacani, Giovanni ; Scope, Alon ; Ferrari, Barbara ; Pupelli, Gaia ; Bassoli, Sara ; Longo, Caterina ; Cesinaro, Anna Maria ; Argenziano, Giuseppe ; Hofmann-Wellenhof, Rainer ; Malvehy, Josep ; Marghoob, Ashfaq A. ; Puig, Susana ; Seidenari, Stefania ; Soyer, H. Peter ; Zalaudek, Iris. / New insights into nevogenesis : In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy. In: Journal of the American Academy of Dermatology. 2009 ; Vol. 61, No. 6. pp. 1001-1013.
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AU - Bassoli, Sara

AU - Longo, Caterina

AU - Cesinaro, Anna Maria

AU - Argenziano, Giuseppe

AU - Hofmann-Wellenhof, Rainer

AU - Malvehy, Josep

AU - Marghoob, Ashfaq A.

AU - Puig, Susana

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AU - Soyer, H. Peter

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