Abstract
Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors. Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one. hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration. In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.
| Original language | English |
|---|---|
| Article number | 312501 |
| Journal | Stem Cells International |
| DOIs | |
| Publication status | Published - 2013 |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Cite this
New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. / Giuliani, Nicola; Lisignoli, Gina; Magnani, Marina; Racano, Costantina; Bolzoni, Marina; Dalla Palma, Benedetta; Spolzino, Angelica; Manferdini, Cristina; Abati, Caterina; Toscani, Denise; Facchini, Andrea; Aversa, Franco.
In: Stem Cells International, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics
AU - Giuliani, Nicola
AU - Lisignoli, Gina
AU - Magnani, Marina
AU - Racano, Costantina
AU - Bolzoni, Marina
AU - Dalla Palma, Benedetta
AU - Spolzino, Angelica
AU - Manferdini, Cristina
AU - Abati, Caterina
AU - Toscani, Denise
AU - Facchini, Andrea
AU - Aversa, Franco
PY - 2013
Y1 - 2013
N2 - Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors. Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one. hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration. In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.
AB - Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors. Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one. hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration. In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=84878741608&partnerID=8YFLogxK
U2 - 10.1155/2013/312501
DO - 10.1155/2013/312501
M3 - Article
C2 - 23766767
AN - SCOPUS:84878741608
JO - Stem Cells International
JF - Stem Cells International
SN - 1687-966X
M1 - 312501
ER -