New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics

Nicola Giuliani, Gina Lisignoli, Marina Magnani, Costantina Racano, Marina Bolzoni, Benedetta Dalla Palma, Angelica Spolzino, Cristina Manferdini, Caterina Abati, Denise Toscani, Andrea Facchini, Franco Aversa

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors. Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one. hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration. In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.

Original languageEnglish
Article number312501
JournalStem Cells International
DOIs
Publication statusPublished - 2013

Fingerprint

Bone Regeneration
Mesenchymal Stromal Cells
Orthopedics
Bone Marrow
Pediatrics
SOX9 Transcription Factor
Transcription Factors
Pluripotent Stem Cells
Pseudarthrosis
Adult Stem Cells
Regenerative Medicine
Chondrocytes
Osteoblasts
Adipocytes
Signal Transduction
Intercellular Signaling Peptides and Proteins
Hormones

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. / Giuliani, Nicola; Lisignoli, Gina; Magnani, Marina; Racano, Costantina; Bolzoni, Marina; Dalla Palma, Benedetta; Spolzino, Angelica; Manferdini, Cristina; Abati, Caterina; Toscani, Denise; Facchini, Andrea; Aversa, Franco.

In: Stem Cells International, 2013.

Research output: Contribution to journalArticle

Giuliani, Nicola ; Lisignoli, Gina ; Magnani, Marina ; Racano, Costantina ; Bolzoni, Marina ; Dalla Palma, Benedetta ; Spolzino, Angelica ; Manferdini, Cristina ; Abati, Caterina ; Toscani, Denise ; Facchini, Andrea ; Aversa, Franco. / New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. In: Stem Cells International. 2013.
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AU - Racano, Costantina

AU - Bolzoni, Marina

AU - Dalla Palma, Benedetta

AU - Spolzino, Angelica

AU - Manferdini, Cristina

AU - Abati, Caterina

AU - Toscani, Denise

AU - Facchini, Andrea

AU - Aversa, Franco

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