New insights into the metastasis-associated 67 kD laminin receptor

Sylvie Ménard, Vincent Castronovo, Elda Tagliabue, Mark E. Sobel

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated by different cell surface molecules, including the monomeric 67 kD laminin receptor. This molecule appears to be very peculiar since so far only a full-length gene encoding a 37 kD precursor protein has been isolated and the mechanism by which the precursor reaches the mature form is not understood. Based on clinical data which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form. The function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalJournal of Cellular Biochemistry
Volume67
Issue number2
DOIs
Publication statusPublished - Nov 1 1997

Fingerprint

Laminin Receptors
Tumors
Neoplasm Metastasis
Molecules
Gene encoding
Laminin
Neoplasms
Integrins
Cells
Genes
Acylation
Protein Precursors
Accessories
Extracellular Matrix
Down-Regulation
Membranes
Therapeutics

Keywords

  • Adhesion receptors
  • Cancer
  • Laminin
  • Ribosomal proteins
  • Tumor progression

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

New insights into the metastasis-associated 67 kD laminin receptor. / Ménard, Sylvie; Castronovo, Vincent; Tagliabue, Elda; Sobel, Mark E.

In: Journal of Cellular Biochemistry, Vol. 67, No. 2, 01.11.1997, p. 155-165.

Research output: Contribution to journalArticle

Ménard, Sylvie ; Castronovo, Vincent ; Tagliabue, Elda ; Sobel, Mark E. / New insights into the metastasis-associated 67 kD laminin receptor. In: Journal of Cellular Biochemistry. 1997 ; Vol. 67, No. 2. pp. 155-165.
@article{9b82386505ba4fd8ba1fef46b0eb2047,
title = "New insights into the metastasis-associated 67 kD laminin receptor",
abstract = "The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated by different cell surface molecules, including the monomeric 67 kD laminin receptor. This molecule appears to be very peculiar since so far only a full-length gene encoding a 37 kD precursor protein has been isolated and the mechanism by which the precursor reaches the mature form is not understood. Based on clinical data which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form. The function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness.",
keywords = "Adhesion receptors, Cancer, Laminin, Ribosomal proteins, Tumor progression",
author = "Sylvie M{\'e}nard and Vincent Castronovo and Elda Tagliabue and Sobel, {Mark E.}",
year = "1997",
month = "11",
day = "1",
doi = "10.1002/(SICI)1097-4644(19971101)67:2<155::AID-JCB1>3.0.CO;2-W",
language = "English",
volume = "67",
pages = "155--165",
journal = "Journal of Cellular Biochemistry",
issn = "0730-2312",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - New insights into the metastasis-associated 67 kD laminin receptor

AU - Ménard, Sylvie

AU - Castronovo, Vincent

AU - Tagliabue, Elda

AU - Sobel, Mark E.

PY - 1997/11/1

Y1 - 1997/11/1

N2 - The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated by different cell surface molecules, including the monomeric 67 kD laminin receptor. This molecule appears to be very peculiar since so far only a full-length gene encoding a 37 kD precursor protein has been isolated and the mechanism by which the precursor reaches the mature form is not understood. Based on clinical data which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form. The function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness.

AB - The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated by different cell surface molecules, including the monomeric 67 kD laminin receptor. This molecule appears to be very peculiar since so far only a full-length gene encoding a 37 kD precursor protein has been isolated and the mechanism by which the precursor reaches the mature form is not understood. Based on clinical data which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form. The function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness.

KW - Adhesion receptors

KW - Cancer

KW - Laminin

KW - Ribosomal proteins

KW - Tumor progression

UR - http://www.scopus.com/inward/record.url?scp=0344247741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344247741&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-4644(19971101)67:2<155::AID-JCB1>3.0.CO;2-W

DO - 10.1002/(SICI)1097-4644(19971101)67:2<155::AID-JCB1>3.0.CO;2-W

M3 - Article

VL - 67

SP - 155

EP - 165

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

SN - 0730-2312

IS - 2

ER -