New insights into the pathogenesis and the therapy of recurrent focal glomerulosclerosis

Flavio Vincenti, Gian Marco Ghiggeri

Research output: Contribution to journalArticlepeer-review

Abstract

Recurrent focal glomerulosclerosis (FSGS) in renal allografts has remained a frustrating and enigmatic disease. Recent studies on gene mutations encoding podocin and other components of the slit-diaphragm in patients with native kidney nephrotic syndrome have underscored the heterogenecity of the idiopathic form of FSGS. While familial FSGS rarely recurs following transplantation, the sporadic variety of FSGS is associated with a 30% recurrence rate. The patients with the sporadic variety of FSGS who have homozygous or complex heterozygous podocin mutations have a low recurrence rate. In the other patients with sporadic FSGS, a more complex and likely multifactorial etiology accounts for the recurrence of FSGS. The role of CD80 expression on podocytes is intriguing but requires confirmation in kidney biopsies of patients with recurrent FSGS. Recent findings on podocin genomics, the permeability factor and CD80 expression may ultimately lead to a better understanding of recurrent FSGS as well as a more effective approach to its prevention and treatment.

Original languageEnglish
Pages (from-to)1179-1185
Number of pages7
JournalAmerican Journal of Transplantation
Volume5
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Focal glomerulosclerosis
  • Permeability factor
  • Recurrent disease

ASJC Scopus subject areas

  • Immunology

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