New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models

Claudia Traidl, Hans F. Merk, Andrea Cavani, Nicolas Hunzelmann

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Allergic contact dermatitis (ACD) is one of the most common skin diseases with a great socioeconomic impact. Although extensively studied, its pathophysiology and the interaction of different cells and factors which lead to sensitization and elicitation reaction are still not completely understood. The advent of transgenic mouse technology has considerably changed the study of ACD. This technology has been used extensively to investigate biomedically important issues in such diverse areas as mammalian development, neurophysiology and immunology. This new approach has already led to fascinating results which are confirmatory but also contradictory to previous thinking on the role of certain cytokines, adhesion and cell surface molecules in the complex pathophysiologic process of ACD. This review will describe how recent experiments employing mice carrying cytokine and accessory molecule transgenes change our current understanding of contact dermatitis which may lead to improved therapeutic strategies. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)300-312
Number of pages13
JournalSkin Pharmacology and Applied Skin Physiology
Volume13
Issue number6
Publication statusPublished - 2000

Fingerprint

Allergic Contact Dermatitis
Contact Dermatitis
Transgenic Mice
Cytokines
Technology
Neurophysiology
Cell Adhesion Molecules
Allergy and Immunology
Transgenes
Skin Diseases
Cell Communication
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models. / Traidl, Claudia; Merk, Hans F.; Cavani, Andrea; Hunzelmann, Nicolas.

In: Skin Pharmacology and Applied Skin Physiology, Vol. 13, No. 6, 2000, p. 300-312.

Research output: Contribution to journalArticle

Traidl, Claudia ; Merk, Hans F. ; Cavani, Andrea ; Hunzelmann, Nicolas. / New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models. In: Skin Pharmacology and Applied Skin Physiology. 2000 ; Vol. 13, No. 6. pp. 300-312.
@article{16186580b5e541a8856e0ea7a2a56a1a,
title = "New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models",
abstract = "Allergic contact dermatitis (ACD) is one of the most common skin diseases with a great socioeconomic impact. Although extensively studied, its pathophysiology and the interaction of different cells and factors which lead to sensitization and elicitation reaction are still not completely understood. The advent of transgenic mouse technology has considerably changed the study of ACD. This technology has been used extensively to investigate biomedically important issues in such diverse areas as mammalian development, neurophysiology and immunology. This new approach has already led to fascinating results which are confirmatory but also contradictory to previous thinking on the role of certain cytokines, adhesion and cell surface molecules in the complex pathophysiologic process of ACD. This review will describe how recent experiments employing mice carrying cytokine and accessory molecule transgenes change our current understanding of contact dermatitis which may lead to improved therapeutic strategies. Copyright (C) 2000 S. Karger AG, Basel.",
author = "Claudia Traidl and Merk, {Hans F.} and Andrea Cavani and Nicolas Hunzelmann",
year = "2000",
language = "English",
volume = "13",
pages = "300--312",
journal = "Skin Pharmacology and Applied Skin Physiology",
issn = "1422-2868",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - New insights into the pathomechanisms of contact dermatitis by the use of transgenic mouse models

AU - Traidl, Claudia

AU - Merk, Hans F.

AU - Cavani, Andrea

AU - Hunzelmann, Nicolas

PY - 2000

Y1 - 2000

N2 - Allergic contact dermatitis (ACD) is one of the most common skin diseases with a great socioeconomic impact. Although extensively studied, its pathophysiology and the interaction of different cells and factors which lead to sensitization and elicitation reaction are still not completely understood. The advent of transgenic mouse technology has considerably changed the study of ACD. This technology has been used extensively to investigate biomedically important issues in such diverse areas as mammalian development, neurophysiology and immunology. This new approach has already led to fascinating results which are confirmatory but also contradictory to previous thinking on the role of certain cytokines, adhesion and cell surface molecules in the complex pathophysiologic process of ACD. This review will describe how recent experiments employing mice carrying cytokine and accessory molecule transgenes change our current understanding of contact dermatitis which may lead to improved therapeutic strategies. Copyright (C) 2000 S. Karger AG, Basel.

AB - Allergic contact dermatitis (ACD) is one of the most common skin diseases with a great socioeconomic impact. Although extensively studied, its pathophysiology and the interaction of different cells and factors which lead to sensitization and elicitation reaction are still not completely understood. The advent of transgenic mouse technology has considerably changed the study of ACD. This technology has been used extensively to investigate biomedically important issues in such diverse areas as mammalian development, neurophysiology and immunology. This new approach has already led to fascinating results which are confirmatory but also contradictory to previous thinking on the role of certain cytokines, adhesion and cell surface molecules in the complex pathophysiologic process of ACD. This review will describe how recent experiments employing mice carrying cytokine and accessory molecule transgenes change our current understanding of contact dermatitis which may lead to improved therapeutic strategies. Copyright (C) 2000 S. Karger AG, Basel.

UR - http://www.scopus.com/inward/record.url?scp=0033663033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033663033&partnerID=8YFLogxK

M3 - Article

C2 - 11096372

AN - SCOPUS:0033663033

VL - 13

SP - 300

EP - 312

JO - Skin Pharmacology and Applied Skin Physiology

JF - Skin Pharmacology and Applied Skin Physiology

SN - 1422-2868

IS - 6

ER -