TY - JOUR
T1 - New Insights on Acute and Chronic Schistosomiasis
T2 - Do We Need a Redefinition?
AU - on behalf of TropNet Schisto Task Force
AU - Gobbi, Federico
AU - Tamarozzi, Francesca
AU - Buonfrate, Dora
AU - van Lieshout, Lisette
AU - Bisoffi, Zeno
AU - Bottieau, Emmanuel
N1 - Funding Information:
This work was supported by the Italian Ministry of Health 'Fondi Ricerca Corrente – Linea 3, progetto 8' to IRCCS Sacro Cuore Don Calabria Hospital. We acknowledge Dr Sara Caldrer for Figure 2 .
Publisher Copyright:
© 2020 The Authors
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - A precise timeframe to differentiate acute schistosomiasis (AS) and chronic schistosomiasis (CS) is not well defined. Based on recent published literature, lung nodular lesions in AS and CS seem to have the same pathophysiology, that is, eggs laid in situ by adult worms, during an ectopic migration. Moreover, the occurrence of lung nodules due to clusters of eggs and the systemic immunoallergic reaction of AS (Katayama syndrome) may be two separate clinical entities, which may overlap during the early phase of infection. Consequently, the classical distinction between AS and CS loses much of its conceptual validity. If adult worms play a more important role in the early phase of the disease the clinical management of AS should probably be revised.
AB - A precise timeframe to differentiate acute schistosomiasis (AS) and chronic schistosomiasis (CS) is not well defined. Based on recent published literature, lung nodular lesions in AS and CS seem to have the same pathophysiology, that is, eggs laid in situ by adult worms, during an ectopic migration. Moreover, the occurrence of lung nodules due to clusters of eggs and the systemic immunoallergic reaction of AS (Katayama syndrome) may be two separate clinical entities, which may overlap during the early phase of infection. Consequently, the classical distinction between AS and CS loses much of its conceptual validity. If adult worms play a more important role in the early phase of the disease the clinical management of AS should probably be revised.
KW - acute and chronic schistosomiasis
KW - Katayama syndrome
KW - lung nodule
KW - neuroschistosomiasis
KW - praziquantel
KW - pulmonary schistosomiasis
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U2 - 10.1016/j.pt.2020.05.009
DO - 10.1016/j.pt.2020.05.009
M3 - Review article
C2 - 32505540
AN - SCOPUS:85085752332
VL - 36
SP - 660
EP - 667
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 8
ER -