New insights on schwann cell development

Kelly R. Monk, M. Laura Feltri, Carla Taveggia

Research output: Contribution to journalArticle

Abstract

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact with axons throughout development. Schwann cells generate the insulating myelin sheath and provide vital trophic support to the neurons that they ensheathe. Schwann cell precursors arise from neural crest progenitor cells, and a highly ordered developmental sequence controls the progression of these cells to become mature myelinating or nonmyelinating Schwann cells. Here, we discuss both seminal discoveries and recent advances in our understanding of the molecular mechanisms that drive Schwann cell development and myelination with a focus on cell-cell and cell-matrix signaling events.

Original languageEnglish
Pages (from-to)1376-1393
Number of pages18
JournalGLIA
Volume63
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Schwann Cells
Neural Crest
Peripheral Nervous System
Myelin Sheath
Neuroglia
Axons
Stem Cells
Neurons

Keywords

  • Immature Schwann cell
  • Myelinating Schwann cell
  • Neural crest
  • Peripheral nervous system
  • Radial sorting
  • Remak Schwann cell
  • Schwann cell
  • Schwann cell precursor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

New insights on schwann cell development. / Monk, Kelly R.; Feltri, M. Laura; Taveggia, Carla.

In: GLIA, Vol. 63, No. 8, 01.08.2015, p. 1376-1393.

Research output: Contribution to journalArticle

Monk, KR, Feltri, ML & Taveggia, C 2015, 'New insights on schwann cell development', GLIA, vol. 63, no. 8, pp. 1376-1393. https://doi.org/10.1002/glia.22852
Monk, Kelly R. ; Feltri, M. Laura ; Taveggia, Carla. / New insights on schwann cell development. In: GLIA. 2015 ; Vol. 63, No. 8. pp. 1376-1393.
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