New insights on the role of luteinizing hormone releasing hormone agonists in premenopausal early breast cancer patients

Giovanni Battista Rossi, Matteo Lambertini, Francesca Poggio

Research output: Contribution to journalArticlepeer-review

Abstract

Luteinising hormone releasing hormone agonists (LH-RHa) are effective in the treatment of advanced endocrine-sensitive breast cancer in premenopausal patients, but their role in the adjuvant setting has remained controversial for a long time. Tamoxifen for 5 years has been traditionally considered the standard endocrine therapy for premenopausal patients and this is still valid for many patients. However, the recently reported SOFT trial has suggested that adding ovarian function suppression (OFS) to tamoxifen could improve DFS in women at sufficient risk to warrant adjuvant chemotherapy and who remained premenopausal after this therapy. The administration of an aromatase inhibitor plus OFS represents an additional therapeutic option for hormone-receptor positive premenopausal breast cancer patients, according to the combined analysis of the SOFT and TEXT trials. Temporary ovarian suppression induced by LH-RHa has been recognized as an effective strategy to preserve ovarian function from the toxic effects of chemotherapy and is now recommended in young breast cancer patients with endocrine-insensitive tumors. In this review, we discuss recent data on the role of LH-RHa in combination with tamoxifen or with an aromatase inhibitor, and we comment on its role as a strategy to preserve ovarian function in young patients candidates for adjuvant or neo-adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalCancer Treatment Reviews
Volume42
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Aromatase inhibitor
  • Breast cancer
  • Endocrine therapy
  • Infertility
  • LH-RH agonists
  • Ovarian ablation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'New insights on the role of luteinizing hormone releasing hormone agonists in premenopausal early breast cancer patients'. Together they form a unique fingerprint.

Cite this