New markers of neonatal neurology

Diego Gazzolo, Raul Abella, Emanuela Marinoni, Romolo Di Iorio, Giovanni Li Volti, Fabio Galvano, Alessandro Frigiola, Francesca Temporini, Luca Moresco, Micaela Colivicchi, Miriam Sabatini, Alberto Ricotti, Maria Chiara Strozzi, Sandro Crivelli, Francesco Maria Risso, Andrea Sannia, Pasquale Florio

Research output: Contribution to journalArticle

Abstract

Hypoxiaischemia HI constitutes the main phenomenon responsible for brainblood barrier permeability modifications leading to cerebral vascular auto-regulation loss in newborns. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation loss leading to cell death and tissue damage. Reperfusion could be critical since organ damage, particularly of the brain, may be amplified during this period. An exaggerated activation of vasoactive agents, of calcium mediated effects could be responsible for reperfusion injury R-I, which, in turns, leads to cerebral hemorrhage and damage. These phenomena represent a common repertoire in newborns complicated by perinatal acute or chronic hypoxia treated by risky procedures such as mechanical ventilation, nitric oxide supplementation, brain cooling, and extracorporeal membrane oxygenation ECMO. Despite accurate monitoring, the post-insult period is crucial, as clinical symptoms and standard monitoring parameters may be silent at a time when brain damage is already occurring and the therapeutic window for pharmacological intervention is limited. Therefore, the measurement of circulating biochemical markers of brain damage, such as vasoactive agents and nervous tissue peptides is eagerly awaited in clinical practice to detect high risk newborns. The present review is aimed at investigating the role of biochemical markers such as adrenomedullin, a vasoactive peptide; S100B, a calcium binding protein, activin A, a glycoprotein, in the cascade of events leading to I-R injury in newborns complicated by perinatal asphyxia.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume22
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 2009

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Keywords

  • Activin A
  • Adrenomedullin
  • Brain damage
  • Newborn
  • Perinatal asphyxia
  • S100B

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Gazzolo, D., Abella, R., Marinoni, E., Di Iorio, R., Li Volti, G., Galvano, F., Frigiola, A., Temporini, F., Moresco, L., Colivicchi, M., Sabatini, M., Ricotti, A., Strozzi, M. C., Crivelli, S., Risso, F. M., Sannia, A., & Florio, P. (2009). New markers of neonatal neurology. Journal of Maternal-Fetal and Neonatal Medicine, 22(SUPPL. 3), 57-61. https://doi.org/10.1080/14767050903181468