New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.

Lucia Brandimarte, Valentina Pierini, Danika Di Giacomo, Chiara Borga, Filomena Nozza, Paolo Gorello, Marco Giordan, Giovanni Cazzaniga, Geertruy Te Kronnie, Roberta La Starza, Cristina Mecucci

Research output: Contribution to journalArticlepeer-review

Abstract

The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent 11q23 and 11q14 chromosome translocations. Deep sequencing recently identified NAP1L1/12q21 as another MLLT10 partner in T-cell acute lymphoblastic leukemia (T-ALL). In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. Gene expression profile signatures of the HNRNPH1- and DDX3X-MLLT10 fusions placed them in the HOXA subgroup. Remarkably, they were highly similar only to PICALM-MLLT10-positive cases. The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific MLLT10 signature within the HOXA subgroup.

Original languageEnglish
Pages (from-to)5064-5067
Number of pages4
JournalBlood
Volume121
Issue number25
DOIs
Publication statusPublished - Jun 20 2013

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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