New monoclonal antibodies and tyrosine kinase inhibitors in B-cell acute lymphoblastic leukemia

Francesco Lanza, Enrico Maffini, Francesco Saraceni, Evita Massari, Michela Rondoni, Giulia Daghia, Attilio Olivieri, Claudio Cerchione, Giovanni Martinelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Patients with acute lymphoblastic leukemia (ALL) are characterized by an unfavorable outcome in the majority of adult cases. Several clinical trials have confirmed the usefulness of a pediatric-type therapy applied to adult patients. Adults present with higher risk features at diagnosis that predispose them to chemotherapy resistance and disease relapse after an initial achievement of complete remission. The recent introduction of novel immune-targeted therapies, including monoclonal antibodies (MoAbs) targeting B cell-associated antigens such as CD19 (blinatumumab) and CD22 (inotuzumab), tyrosine kinase inhibitors targeting BCR-ABL1 tyrosine kinase, bispecific antibodies and chimeric antigen receptor T- cell therapy (CAR-T), circumvent B-ALL cell chemo-refractoriness through novel mechanisms of action, potentially eradicating minimal residual disease (MRD) and enabling more patients to receive allogeneic hematopoietic stem cell transplantation and to achieve a better clinical outcome.

Original languageEnglish
Pages (from-to)478-490
Number of pages13
JournalMinerva Medica
Volume111
Issue number5
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Acute Disease
  • Adult
  • Antibodies, Bispecific/therapeutic use
  • Antibodies, Monoclonal/therapeutic use
  • Clinical Trials as Topic
  • Drug Resistance, Neoplasm
  • Fusion Proteins, bcr-abl/antagonists & inhibitors
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Imidazoles/therapeutic use
  • Immunotherapy, Adoptive/methods
  • Inotuzumab Ozogamicin/therapeutic use
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
  • Protein Kinase Inhibitors/therapeutic use
  • Pyridazines/therapeutic use
  • Recurrence
  • Sialic Acid Binding Ig-like Lectin 2/antagonists & inhibitors

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