New Myocardial Deformation by 2D Multi-layer Speckle-Tracking Analysis in Healthy Patients: Normal Reference Values and Their Physiologic Determinants

Roxana Cristina Rimbaş, Sorina Mihăilă-Baldea, Lucia Ştefania Magda, Simona Ionela Vişoiu, Denisa Muraru, Dragoş Vinereanu

Research output: Contribution to journalArticlepeer-review

Abstract

There are limited data regarding intrinsic changes of the left (LV) and right ventricular (RV) deformation assessed layer-by-layer. We designed a prospective multi-centric study, using a new multi-layer 2D-speckle-tracking-echo (MSTE). We investigated the impact of different physiologic parameters on layer-specific LV/RV myocardial deformation and synchrony, in a large group of healty subjects. 151 subjects were feasible for MSTE, divided in 4 groups: <40 yrs, 41 to 50 yrs, 51 to 60, and >61 yrs. We found a significant higher LV dyssynchrony index with age. In all groups, an endo-epicardial gradient was present in longitudinal LV/RV and circumferential deformation, with higher values in endocardial layer (p<0.001). There were no differences in deformation with age in all layers. We provided normal reference values for a new index of LV dyssynchrony, and also for RV longitudinal, LV circumferential and longitudinal layer-specific deformation, which can be further used when assessing subclinical dysfunction in myocardial diseases.

Original languageEnglish
Pages (from-to)818-827
Number of pages10
JournalUltrasound in Medicine and Biology
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Dyssynchrony index
  • Left ventricle
  • Multilayer analysis
  • Myocardial deformation
  • Reference values
  • Right ventricle
  • Speckle-tracking echocardiography

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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