New-onset angina preceding acute myocardial infarction is associated with improved contractile recovery after thrombolysis

Claudio Napoli, A. Liguori, M. Chiariello, N. Di Ieso, M. Condorelli, G. Ambrosio

Research output: Contribution to journalArticle

Abstract

Background. Ischaemic preconditioning reduces myocardial infarct size in animal models. Clinical data suggest that episodes of angina immediately before acute myocardial infarction may be associated with smaller infarct size in man. However, it is unclear whether ischaemic episodes preceding acute myocardial infarction also affect contractile recovery in patients. Objective. In this study we investigated the recovery of regional myocardial function after thrombolysis in two groups of patients at their first Q-wave acute myocardial infarction; in one group (n = 42) myocardial infarction occurred unheralded, whereas patients of the second group (n = 48) had experienced new-onset angina in the 48 h that preceded infarction. Echocardiographic analysis of myocardial regional function in the infarct area was done at 2, 24 and 72 h after thrombolysis, and at 1 week, and 1 and 3 months follow-up.

Original languageEnglish
Pages (from-to)411-419
Number of pages9
JournalEuropean Heart Journal
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 1998

Keywords

  • Coronary heart disease
  • Preconditioning
  • Regional function
  • Stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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