Abstract
Observational studies have provided evidence that a consistent fraction (approximately 15-20%) of hypertensive patients displays a glucose intolerance state that may be aggravated by antihypertensive drug regimens based on thiazide diuretics or beta-blockers. This review examines the relative and absolute diabetogenic effects of antihypertensive drugs, by comparing the impact of 'new' (calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists) versus 'old' (diuretics and beta-blockers) drugs on new-onset diabetes in recent clinical trials. Evidence is provided that compared with diuretics and beta-blockers, new-onset diabetes is less common with 'new' drugs, and that conventional antihypertensive compounds, particularly when combined together, may amplify the natural time-dependent tendency towards the development of this metabolic disease. This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of antihypertensive drug-induced diabetes.
Original language | English |
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Pages (from-to) | 3-10 |
Number of pages | 8 |
Journal | Journal of Hypertension |
Volume | 24 |
Issue number | 1 |
Publication status | Published - Jan 2006 |
Keywords
- Angiotensin inhibitors
- Angiotensin-converting enzyme inhibitors
- Beta-blockers
- Calcium antagonists
- Clinical trials
- Diabetes
- Diuretics
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology