Abstract
Observational studies have provided evidence that a consistent fraction (approximately 15-20%) of hypertensive patients displays a glucose intolerance state that may be aggravated by antihypertensive drug regimens based on thiazide diuretics or beta-blockers. This review examines the relative and absolute diabetogenic effects of antihypertensive drugs, by comparing the impact of 'new' (calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists) versus 'old' (diuretics and beta-blockers) drugs on new-onset diabetes in recent clinical trials. Evidence is provided that compared with diuretics and beta-blockers, new-onset diabetes is less common with 'new' drugs, and that conventional antihypertensive compounds, particularly when combined together, may amplify the natural time-dependent tendency towards the development of this metabolic disease. This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of antihypertensive drug-induced diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 3-10 |
| Number of pages | 8 |
| Journal | Journal of Hypertension |
| Volume | 24 |
| Issue number | 1 |
| Publication status | Published - Jan 2006 |
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Keywords
- Angiotensin inhibitors
- Angiotensin-converting enzyme inhibitors
- Beta-blockers
- Calcium antagonists
- Clinical trials
- Diabetes
- Diuretics
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology
Cite this
New-onset diabetes and antihypertensive drugs. / Mancia, Giuseppe; Grassi, Guido; Zanchetti, Alberto.
In: Journal of Hypertension, Vol. 24, No. 1, 01.2006, p. 3-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New-onset diabetes and antihypertensive drugs
AU - Mancia, Giuseppe
AU - Grassi, Guido
AU - Zanchetti, Alberto
PY - 2006/1
Y1 - 2006/1
N2 - Observational studies have provided evidence that a consistent fraction (approximately 15-20%) of hypertensive patients displays a glucose intolerance state that may be aggravated by antihypertensive drug regimens based on thiazide diuretics or beta-blockers. This review examines the relative and absolute diabetogenic effects of antihypertensive drugs, by comparing the impact of 'new' (calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists) versus 'old' (diuretics and beta-blockers) drugs on new-onset diabetes in recent clinical trials. Evidence is provided that compared with diuretics and beta-blockers, new-onset diabetes is less common with 'new' drugs, and that conventional antihypertensive compounds, particularly when combined together, may amplify the natural time-dependent tendency towards the development of this metabolic disease. This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of antihypertensive drug-induced diabetes.
AB - Observational studies have provided evidence that a consistent fraction (approximately 15-20%) of hypertensive patients displays a glucose intolerance state that may be aggravated by antihypertensive drug regimens based on thiazide diuretics or beta-blockers. This review examines the relative and absolute diabetogenic effects of antihypertensive drugs, by comparing the impact of 'new' (calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists) versus 'old' (diuretics and beta-blockers) drugs on new-onset diabetes in recent clinical trials. Evidence is provided that compared with diuretics and beta-blockers, new-onset diabetes is less common with 'new' drugs, and that conventional antihypertensive compounds, particularly when combined together, may amplify the natural time-dependent tendency towards the development of this metabolic disease. This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of antihypertensive drug-induced diabetes.
KW - Angiotensin inhibitors
KW - Angiotensin-converting enzyme inhibitors
KW - Beta-blockers
KW - Calcium antagonists
KW - Clinical trials
KW - Diabetes
KW - Diuretics
UR - http://www.scopus.com/inward/record.url?scp=29244436688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29244436688&partnerID=8YFLogxK
M3 - Article
C2 - 16331092
AN - SCOPUS:29244436688
VL - 24
SP - 3
EP - 10
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 1
ER -