New-onset left atrial enlargement in a general population

Michele Bombelli; Cesare Cuspidi; Rita Facchetti; Carla Sala; Marijana Tadic; Gianmaria Brambilla; Annalisa Re; Paolo Villa; Guido Grassi; Giuseppe Mancia

doi:10.1097/HJH.0000000000001022

New-onset left atrial enlargement in a general population

Michele Bombelli, Cesare Cuspidi, Rita Facchetti, Carla Sala, Marijana Tadic, Gianmaria Brambilla, Annalisa Re, Paolo Villa, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journal › Article › peer-review

Abstract

AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?

Original language	English
Journal	Journal of Hypertension
DOIs	https://doi.org/10.1097/HJH.0000000000001022
Publication status	Accepted/In press - Jul 1 2016

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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@article{fe51b9e42e564c2ca939399e32ac1c29,

title = "New-onset left atrial enlargement in a general population",

abstract = "AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?",

author = "Michele Bombelli and Cesare Cuspidi and Rita Facchetti and Carla Sala and Marijana Tadic and Gianmaria Brambilla and Annalisa Re and Paolo Villa and Guido Grassi and Giuseppe Mancia",

year = "2016",

month = jul,

day = "1",

doi = "10.1097/HJH.0000000000001022",

language = "English",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - New-onset left atrial enlargement in a general population

AU - Bombelli, Michele

AU - Cuspidi, Cesare

AU - Facchetti, Rita

AU - Sala, Carla

AU - Tadic, Marijana

AU - Brambilla, Gianmaria

AU - Re, Annalisa

AU - Villa, Paolo

AU - Grassi, Guido

AU - Mancia, Giuseppe

PY - 2016/7/1

Y1 - 2016/7/1

N2 - AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?

AB - AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?

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