New-onset left atrial enlargement in a general population

Michele Bombelli, Cesare Cuspidi, Rita Facchetti, Carla Sala, Marijana Tadic, Gianmaria Brambilla, Annalisa Re, Paolo Villa, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?

Original languageEnglish
Pages (from-to)1838-1845
Number of pages8
JournalJournal of Hypertension
Issue number9
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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