New-onset left atrial enlargement in a general population

Michele Bombelli, Cesare Cuspidi, Rita Facchetti, Carla Sala, Marijana Tadic, Gianmaria Brambilla, Annalisa Re, Paolo Villa, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?

Original languageEnglish
Pages (from-to)1838-1845
Number of pages8
JournalJournal of Hypertension
Volume34
Issue number9
DOIs
Publication statusPublished - 2016

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Heart Atria
Population
Blood Glucose
Fasting
Reference Values
Multivariate Analysis
Odds Ratio
Confidence Intervals
Blood Pressure
Morbidity
Mortality
Incidence

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Bombelli, M., Cuspidi, C., Facchetti, R., Sala, C., Tadic, M., Brambilla, G., ... Mancia, G. (2016). New-onset left atrial enlargement in a general population. Journal of Hypertension, 34(9), 1838-1845. https://doi.org/10.1097/HJH.0000000000001022

New-onset left atrial enlargement in a general population. / Bombelli, Michele; Cuspidi, Cesare; Facchetti, Rita; Sala, Carla; Tadic, Marijana; Brambilla, Gianmaria; Re, Annalisa; Villa, Paolo; Grassi, Guido; Mancia, Giuseppe.

In: Journal of Hypertension, Vol. 34, No. 9, 2016, p. 1838-1845.

Research output: Contribution to journalArticle

Bombelli, M, Cuspidi, C, Facchetti, R, Sala, C, Tadic, M, Brambilla, G, Re, A, Villa, P, Grassi, G & Mancia, G 2016, 'New-onset left atrial enlargement in a general population', Journal of Hypertension, vol. 34, no. 9, pp. 1838-1845. https://doi.org/10.1097/HJH.0000000000001022
Bombelli, Michele ; Cuspidi, Cesare ; Facchetti, Rita ; Sala, Carla ; Tadic, Marijana ; Brambilla, Gianmaria ; Re, Annalisa ; Villa, Paolo ; Grassi, Guido ; Mancia, Giuseppe. / New-onset left atrial enlargement in a general population. In: Journal of Hypertension. 2016 ; Vol. 34, No. 9. pp. 1838-1845.
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AU - Bombelli, Michele

AU - Cuspidi, Cesare

AU - Facchetti, Rita

AU - Sala, Carla

AU - Tadic, Marijana

AU - Brambilla, Gianmaria

AU - Re, Annalisa

AU - Villa, Paolo

AU - Grassi, Guido

AU - Mancia, Giuseppe

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N2 - AIM:: Increased left atrium diameter (LAD) is associated with elevated risk of cardiovascular morbidity and mortality. We evaluated new-onset left atrium enlargement (LAE) and their correlates over a 10-year period in participants of the general population enrolled in the Pressioni Monitorate e Loro Associazioni study. METHODS:: The study included 1045 participants with normal LAD at baseline evaluation having a readable echocardiogram at the end of follow-up. Cut-points for abnormal LAD were derived from reference values recommended by American Society of Echocardiography. RESULTS:: Over a 10-year period, 123 participants (11.8%) progressed to LAE. The incidence of new-onset LAE increased significantly from the lowest to the highest tertile of baseline office, home and 24-h blood pressure (BP); BMI; fasting blood glucose and left ventricular mass index (LVMI). In multivariate analysis, baseline LAD [odds ratio (OR) 3.18, confidence interval (CI) 2.26–4.47, P?

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