New orally active monoamine oxidase (MAO) inhibitors

A. Jori, A. Bonaccorsi, L. Valzelli, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Four derivatives of benzoyl and anisoyl hydrazine, have been selected for a comparison with phenelzine and pheniprazine. The new compounds are potentiators of tryptamine and inhibitors of reserpine with a therapeutic index much more favorable than in the case of phenelzine and pheniprazine when the oral route of administration is used. The new compounds inhibit MAO activity and increase brain serotonin and noradrenaline levels.

Original languageEnglish
Pages (from-to)611-617
Number of pages7
JournalLife Sciences
Volume2
Issue number8
Publication statusPublished - Aug 1963

ASJC Scopus subject areas

  • Pharmacology

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