New perspectives for selective NCX activators in neurodegenerative diseases

Lucio Annunziato, Agnese Secondo, Giuseppe Pignataro, Antonella Scorziello, Pasquale Molinaro

Research output: Contribution to journalArticlepeer-review

Abstract

The Na+/Ca2+ exchanger plays a relevant role in several neurological disorders, thus the pharmacological modulation of its isoforms might represent a promising strategy to ameliorate the course of some neurological pathologies including stroke, neonatal hypoxia, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer Disease (AD), and spinal muscular atrophy (SMA). This review will summarize heterocyclic, peptidergic, genetic and epigenetic compounds activating or inhibiting the expression/activity of each NCX isoform. In addition, we will focus our attention on the development of new strategies aimed to ameliorate the pathophysiological conditions in which NCX isoform changes are found.

Original languageEnglish
Article number102170
JournalCell Calcium
Volume87
DOIs
Publication statusPublished - May 2020

Keywords

  • Drug development
  • NCX1
  • NCX2
  • NCX3
  • Neurodegenerative diseases
  • Stroke

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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