Tumori polmonari non a piccole cellule con istotipo non squamoso. Nuove prospettive nel trattamento di seconda linea

Translated title of the contribution: New perspectives in second-line treatment in non-squamous non-small cell lung cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

The treatment options for patients with non-squamous non-small cell lung cancer (NSCLC) in second-line have been limited for a long time. Docetaxel, pemetrexed and erlotinib are the standard second-line treatment. Docetaxel is frequently used although it is associated with an unfavorable safety profle. Recently, the results from the trial CheckMate 057 with nivolumab, an anti-PD-1 inhibitor, has increased the therapeutic options for patients with non-squamous NSCLC in the second-line setting. The results of this randomized phase III trial comparing nivolumab vs docetaxel have deeply changed our current clinical practice. This review explores the recent fndings about nivolumab in this setting by analyzing the results of CheckMate 057 trial fndings and discussing their implications in clinical practice. Particular attention has been given to effcacy, patients selection, toxicity profle, and quality of life.

Translated title of the contributionNew perspectives in second-line treatment in non-squamous non-small cell lung cancer
Original languageItalian
Pages (from-to)641-646
Number of pages6
JournalRecenti Progressi in Medicina
Volume107
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

ASJC Scopus subject areas

  • Medicine(all)

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