Abstract
Autologous skeletal myoblast transplantation may be used to ameliorate the healing process following myocardium infarct and, hopefully, cardiomyopathies. Despite successful animal experimentation, several issues need to be addressed in clinical settings, i.e., the impact of the delivery route, the extent of short- and long-term survival, and differentiation of the injected skeletal myoblasts. The authors offer some new hypotheses resulting from basic research, i.e., where and when to inject the myogenic cells, whatever their source, how to decrease new myofiber atrophy and improve their regeneration. Although these new hypotheses still need to be tested in humans, they may be decisive for future experimental studies and will lead to making endovascular cell implantation a more effective way to treat ischemic heart disease and failure.
| Original language | English |
|---|---|
| Pages (from-to) | 84-87 |
| Number of pages | 4 |
| Journal | Cardiovascular Radiation Medicine |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2004 |
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Keywords
- Cellular cardiomyoplasty
- Myocardial infarction
- Skeletal myofiber regeneration
- Stem cells
ASJC Scopus subject areas
- Molecular Medicine
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
New perspectives in the treatment of damaged myocardium using autologous skeletal myoblasts. / Rigatelli, Gianluca; Rossini, Katia; Vindigni, Vincenzo; Mazzoleni, Francesco; Rigatelli, Giorgio; Carraro, Ugo.
In: Cardiovascular Radiation Medicine, Vol. 5, No. 2, 04.2004, p. 84-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New perspectives in the treatment of damaged myocardium using autologous skeletal myoblasts
AU - Rigatelli, Gianluca
AU - Rossini, Katia
AU - Vindigni, Vincenzo
AU - Mazzoleni, Francesco
AU - Rigatelli, Giorgio
AU - Carraro, Ugo
PY - 2004/4
Y1 - 2004/4
N2 - Autologous skeletal myoblast transplantation may be used to ameliorate the healing process following myocardium infarct and, hopefully, cardiomyopathies. Despite successful animal experimentation, several issues need to be addressed in clinical settings, i.e., the impact of the delivery route, the extent of short- and long-term survival, and differentiation of the injected skeletal myoblasts. The authors offer some new hypotheses resulting from basic research, i.e., where and when to inject the myogenic cells, whatever their source, how to decrease new myofiber atrophy and improve their regeneration. Although these new hypotheses still need to be tested in humans, they may be decisive for future experimental studies and will lead to making endovascular cell implantation a more effective way to treat ischemic heart disease and failure.
AB - Autologous skeletal myoblast transplantation may be used to ameliorate the healing process following myocardium infarct and, hopefully, cardiomyopathies. Despite successful animal experimentation, several issues need to be addressed in clinical settings, i.e., the impact of the delivery route, the extent of short- and long-term survival, and differentiation of the injected skeletal myoblasts. The authors offer some new hypotheses resulting from basic research, i.e., where and when to inject the myogenic cells, whatever their source, how to decrease new myofiber atrophy and improve their regeneration. Although these new hypotheses still need to be tested in humans, they may be decisive for future experimental studies and will lead to making endovascular cell implantation a more effective way to treat ischemic heart disease and failure.
KW - Cellular cardiomyoplasty
KW - Myocardial infarction
KW - Skeletal myofiber regeneration
KW - Stem cells
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UR - http://www.scopus.com/inward/citedby.url?scp=5344257545&partnerID=8YFLogxK
U2 - 10.1016/j.carrad.2004.05.003
DO - 10.1016/j.carrad.2004.05.003
M3 - Article
VL - 5
SP - 84
EP - 87
JO - Cardiovascular Radiation Medicine
JF - Cardiovascular Radiation Medicine
SN - 1522-1865
IS - 2
ER -