New perspectives in the treatment of damaged myocardium using autologous skeletal myoblasts

Gianluca Rigatelli, Katia Rossini, Vincenzo Vindigni, Francesco Mazzoleni, Giorgio Rigatelli, Ugo Carraro

Research output: Contribution to journalArticle

Abstract

Autologous skeletal myoblast transplantation may be used to ameliorate the healing process following myocardium infarct and, hopefully, cardiomyopathies. Despite successful animal experimentation, several issues need to be addressed in clinical settings, i.e., the impact of the delivery route, the extent of short- and long-term survival, and differentiation of the injected skeletal myoblasts. The authors offer some new hypotheses resulting from basic research, i.e., where and when to inject the myogenic cells, whatever their source, how to decrease new myofiber atrophy and improve their regeneration. Although these new hypotheses still need to be tested in humans, they may be decisive for future experimental studies and will lead to making endovascular cell implantation a more effective way to treat ischemic heart disease and failure.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalCardiovascular Radiation Medicine
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2004

Keywords

  • Cellular cardiomyoplasty
  • Myocardial infarction
  • Skeletal myofiber regeneration
  • Stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

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