TY - JOUR
T1 - New perspectives on amyloid-β dynamics after acute brain injury
T2 - Moving between experimental approaches and studies in the human brain
AU - Magnoni, Sandra
AU - Brody, David L.
PY - 2010/9
Y1 - 2010/9
N2 - The links between traumatic brain injury and Alzheimer disease have been of great interest for many years. However, the importance of amyloid-β- related neurodegenerative pathophysiologic processes after traumatic brain injury is still unknown. In this review, we present a brief overview of the scientific evidence regarding traumatic brain injury as a contributor to Alzheimer disease and describe recent results showing significant changes in brain extracellular amyloid-β dynamics in patients with severe brain injury. We then discuss the clinical significance of these findings with their implications for translational neurobiology and conclude with further directions for traumatic brain injury and Alzheimer disease research.
AB - The links between traumatic brain injury and Alzheimer disease have been of great interest for many years. However, the importance of amyloid-β- related neurodegenerative pathophysiologic processes after traumatic brain injury is still unknown. In this review, we present a brief overview of the scientific evidence regarding traumatic brain injury as a contributor to Alzheimer disease and describe recent results showing significant changes in brain extracellular amyloid-β dynamics in patients with severe brain injury. We then discuss the clinical significance of these findings with their implications for translational neurobiology and conclude with further directions for traumatic brain injury and Alzheimer disease research.
UR - http://www.scopus.com/inward/record.url?scp=77957028556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957028556&partnerID=8YFLogxK
U2 - 10.1001/archneurol.2010.214
DO - 10.1001/archneurol.2010.214
M3 - Article
C2 - 20837849
AN - SCOPUS:77957028556
VL - 67
SP - 1068
EP - 1073
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 9
ER -