New phosphorylated derivatives of carboxymethylcellulose with osteogenic activity

Gemma Leone; Paola Torricelli; Roberto Giardino; Rolando Barbucci

doi:10.1002/pat.1041

New phosphorylated derivatives of carboxymethylcellulose with osteogenic activity

Gemma Leone, Paola Torricelli, Roberto Giardino, Rolando Barbucci

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

New phosphorylated derivatives of carboxymethylcellulose (CMC) and amidic CMC were realized using trisodium trimetaphosphate (STMP) as the phosphating agent. The new polysaccharides were characterized by infrared spectroscopy and elemental analysis. The characterized polysaccharides were then crosslinked and their rheological and swelling properties determined. The presence of phosphate groups made the three-dimensional structures more compact and harder than the corresponding non-phosphated hydrogels. Evaluation of the bioactivity of phosphorylated hydrogels toward osteoblast-like cells (MG63) showed a significant increase in the osteocalcin production.

Original language	English
Pages (from-to)	824-830
Number of pages	7
Journal	Polymers for Advanced Technologies
Volume	19
Issue number	7
DOIs	https://doi.org/10.1002/pat.1041
Publication status	Published - Jul 2008

Keywords

Bone regeneration
Phosphorilation
Polysaccharide

ASJC Scopus subject areas

Polymers and Plastics

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abstract = "New phosphorylated derivatives of carboxymethylcellulose (CMC) and amidic CMC were realized using trisodium trimetaphosphate (STMP) as the phosphating agent. The new polysaccharides were characterized by infrared spectroscopy and elemental analysis. The characterized polysaccharides were then crosslinked and their rheological and swelling properties determined. The presence of phosphate groups made the three-dimensional structures more compact and harder than the corresponding non-phosphated hydrogels. Evaluation of the bioactivity of phosphorylated hydrogels toward osteoblast-like cells (MG63) showed a significant increase in the osteocalcin production.",

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AU - Torricelli, Paola

AU - Giardino, Roberto

AU - Barbucci, Rolando

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AB - New phosphorylated derivatives of carboxymethylcellulose (CMC) and amidic CMC were realized using trisodium trimetaphosphate (STMP) as the phosphating agent. The new polysaccharides were characterized by infrared spectroscopy and elemental analysis. The characterized polysaccharides were then crosslinked and their rheological and swelling properties determined. The presence of phosphate groups made the three-dimensional structures more compact and harder than the corresponding non-phosphated hydrogels. Evaluation of the bioactivity of phosphorylated hydrogels toward osteoblast-like cells (MG63) showed a significant increase in the osteocalcin production.

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KW - Phosphorilation

KW - Polysaccharide

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