Platelets possess many enzymatic activities which allow them to metabolize sugars, lipids, proteins and nucleotides. The presently available knowledge of the energy metabolism of platelets and of the role of adenine nucleotides in platelet function is briefly summarized. Platelet adenine nucleotides are compartmentalized: one nucleotide pool participates in basic platelet metabolism and is retained by the cell during the 'release reaction' (metabolically active pool); another pool does not participate in metabolism and is extruded from the cell during the 'release reaction' (metabolically inactive pool or storage pool). The process by which platelet nucleotides (mainly ADP and ATP) are extruded from the platelets ('release reaction') was tentatively divided into 4 phases: induction, transmission, specific energy production and extrusion. A defect in any one or more stages in this sequence could account for an impairment of platelet aggregation. The data available in the literature (51 patients with prolonged bleeding time, normal platelet count, and one or more abnormal platelet aggregation tests) were analyzed. These 'new' platelet diseases seem to be different from 'old' congenital disorders such as Glanzmann's thrombasthenia and von Willebrand's disease.
|Number of pages||10|
|Journal||Acta Vitaminologica et Enzymologica|
|Publication status||Published - 1973|
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