New positron emission tomography derived parameters as predictive factors for recurrence in resected stage i non-small cell lung cancer

G. Melloni, A. M S Gajate, S. Sestini, F. Gallivanone, A. Bandiera, C. Landoni, P. Muriana, L. Gianolli, P. Zannini

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background The recurrence rate for stage I non-small cell lung cancer is high, with 20-40% of patients that relapse after surgery. The aim of this study was to evaluate new F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) derived parameters, such as standardized uptake value index (SUV index), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), as predictive factors for recurrence in resected stage I non-small cell lung cancer. Methods We retrospectively reviewed 99 resected stage I non-small cell lung cancer patients that were grouped by SUVindex, TLG and MTV above or below their median value. Disease free survival was evaluated as primary end point. Results The 5-year overall survival and the 5-year disease free survival rates were 62% and 73%, respectively. The median SUV index, MTL and TLG were 2.73, 2.95 and 9.61, respectively. Patients with low SUVindex, MTV and TLG were more likely to have smaller tumors (p ≤ 0.001). Univariate analysis demonstrated that SUVindex (p = 0.027), MTV (p = 0.014) and TLG (p = 0.006) were significantly related to recurrence showing a better predictive performance than SUVmax (p = 0.031). The 5-year disease free survival rates in patients with low and high SUVindex, MTV and TLG were 84% and 59%, 86% and 62% and 88% and 60%, respectively. The multivariate analysis showed that only TLG was an independent prognostic factor (p = 0.014) with a hazard ratio of 4.782. Conclusion Of the three PET-derived parameters evaluated, TLG seems to be the most accurate in stratifying surgically treated stage I non-small cell lung cancer patients according to their risk of recurrence.

Original languageEnglish
Pages (from-to)1254-1261
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2013

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Glycolysis
Non-Small Cell Lung Carcinoma
Positron-Emission Tomography
Recurrence
Tumor Burden
Disease-Free Survival
Survival Rate
Fluorodeoxyglucose F18
Multivariate Analysis
Survival

Keywords

  • Imaging
  • Non-small cell lung cancer
  • PET
  • Prognosis
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

New positron emission tomography derived parameters as predictive factors for recurrence in resected stage i non-small cell lung cancer. / Melloni, G.; Gajate, A. M S; Sestini, S.; Gallivanone, F.; Bandiera, A.; Landoni, C.; Muriana, P.; Gianolli, L.; Zannini, P.

In: European Journal of Surgical Oncology, Vol. 39, No. 11, 11.2013, p. 1254-1261.

Research output: Contribution to journalArticle

Melloni, G. ; Gajate, A. M S ; Sestini, S. ; Gallivanone, F. ; Bandiera, A. ; Landoni, C. ; Muriana, P. ; Gianolli, L. ; Zannini, P. / New positron emission tomography derived parameters as predictive factors for recurrence in resected stage i non-small cell lung cancer. In: European Journal of Surgical Oncology. 2013 ; Vol. 39, No. 11. pp. 1254-1261.
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abstract = "Background The recurrence rate for stage I non-small cell lung cancer is high, with 20-40{\%} of patients that relapse after surgery. The aim of this study was to evaluate new F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) derived parameters, such as standardized uptake value index (SUV index), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), as predictive factors for recurrence in resected stage I non-small cell lung cancer. Methods We retrospectively reviewed 99 resected stage I non-small cell lung cancer patients that were grouped by SUVindex, TLG and MTV above or below their median value. Disease free survival was evaluated as primary end point. Results The 5-year overall survival and the 5-year disease free survival rates were 62{\%} and 73{\%}, respectively. The median SUV index, MTL and TLG were 2.73, 2.95 and 9.61, respectively. Patients with low SUVindex, MTV and TLG were more likely to have smaller tumors (p ≤ 0.001). Univariate analysis demonstrated that SUVindex (p = 0.027), MTV (p = 0.014) and TLG (p = 0.006) were significantly related to recurrence showing a better predictive performance than SUVmax (p = 0.031). The 5-year disease free survival rates in patients with low and high SUVindex, MTV and TLG were 84{\%} and 59{\%}, 86{\%} and 62{\%} and 88{\%} and 60{\%}, respectively. The multivariate analysis showed that only TLG was an independent prognostic factor (p = 0.014) with a hazard ratio of 4.782. Conclusion Of the three PET-derived parameters evaluated, TLG seems to be the most accurate in stratifying surgically treated stage I non-small cell lung cancer patients according to their risk of recurrence.",
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T1 - New positron emission tomography derived parameters as predictive factors for recurrence in resected stage i non-small cell lung cancer

AU - Melloni, G.

AU - Gajate, A. M S

AU - Sestini, S.

AU - Gallivanone, F.

AU - Bandiera, A.

AU - Landoni, C.

AU - Muriana, P.

AU - Gianolli, L.

AU - Zannini, P.

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N2 - Background The recurrence rate for stage I non-small cell lung cancer is high, with 20-40% of patients that relapse after surgery. The aim of this study was to evaluate new F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) derived parameters, such as standardized uptake value index (SUV index), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), as predictive factors for recurrence in resected stage I non-small cell lung cancer. Methods We retrospectively reviewed 99 resected stage I non-small cell lung cancer patients that were grouped by SUVindex, TLG and MTV above or below their median value. Disease free survival was evaluated as primary end point. Results The 5-year overall survival and the 5-year disease free survival rates were 62% and 73%, respectively. The median SUV index, MTL and TLG were 2.73, 2.95 and 9.61, respectively. Patients with low SUVindex, MTV and TLG were more likely to have smaller tumors (p ≤ 0.001). Univariate analysis demonstrated that SUVindex (p = 0.027), MTV (p = 0.014) and TLG (p = 0.006) were significantly related to recurrence showing a better predictive performance than SUVmax (p = 0.031). The 5-year disease free survival rates in patients with low and high SUVindex, MTV and TLG were 84% and 59%, 86% and 62% and 88% and 60%, respectively. The multivariate analysis showed that only TLG was an independent prognostic factor (p = 0.014) with a hazard ratio of 4.782. Conclusion Of the three PET-derived parameters evaluated, TLG seems to be the most accurate in stratifying surgically treated stage I non-small cell lung cancer patients according to their risk of recurrence.

AB - Background The recurrence rate for stage I non-small cell lung cancer is high, with 20-40% of patients that relapse after surgery. The aim of this study was to evaluate new F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) derived parameters, such as standardized uptake value index (SUV index), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), as predictive factors for recurrence in resected stage I non-small cell lung cancer. Methods We retrospectively reviewed 99 resected stage I non-small cell lung cancer patients that were grouped by SUVindex, TLG and MTV above or below their median value. Disease free survival was evaluated as primary end point. Results The 5-year overall survival and the 5-year disease free survival rates were 62% and 73%, respectively. The median SUV index, MTL and TLG were 2.73, 2.95 and 9.61, respectively. Patients with low SUVindex, MTV and TLG were more likely to have smaller tumors (p ≤ 0.001). Univariate analysis demonstrated that SUVindex (p = 0.027), MTV (p = 0.014) and TLG (p = 0.006) were significantly related to recurrence showing a better predictive performance than SUVmax (p = 0.031). The 5-year disease free survival rates in patients with low and high SUVindex, MTV and TLG were 84% and 59%, 86% and 62% and 88% and 60%, respectively. The multivariate analysis showed that only TLG was an independent prognostic factor (p = 0.014) with a hazard ratio of 4.782. Conclusion Of the three PET-derived parameters evaluated, TLG seems to be the most accurate in stratifying surgically treated stage I non-small cell lung cancer patients according to their risk of recurrence.

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KW - PET

KW - Prognosis

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