New prediction tools and treatment for ACS patients with plaque erosion

Rocco Vergallo, Ik Kyung Jang, Filippo Crea

Research output: Contribution to journalReview articlepeer-review


For decades, we have known from autopsy observations that the proximate cause of the majority of acute coronary syndromes ( ACS) is occlusive thrombosis generated by plaque rupture or, less frequently, superficial erosion. Patients with ACS caused by plaque erosion seem to have a better long-term prognosis compared to those with plaque rupture, and may be stabilized by dual antiplatelet therapy without the need for stenting in a non-trivial proportion of cases, limiting the expenses and potential complications of invasive procedures. The accurate prediction of plaque erosion and the identification of specific biomarkers that could be used at the point-of-care without the need of invasive imaging would take us a step closer to the holy grail of precision medicine in patients with ACS.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
Publication statusPublished - Feb 2021


  • Acute coronary syndrome
  • Optical coherence tomography
  • Plaque erosion
  • Precision medicine
  • Prediction tools
  • Tailored therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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