Nuove prospettive nella prevenzione del carcinoma colorettale: Lo screening delle lesioni precancerose mediante biopsia rettale e la chemioprevenzione con inibitori COX2

Translated title of the contribution: New prospects in the prevention of colorectal cancer: The screening for precancerous lesions by rectal biopsy and chemoprevention with COX2 inhibitors

Salvatore Berretta, Filippo Catalano, Massimiliano Berretta, Emilia Barbagallo, Rossella Fisichella, Santo Bonanno

Research output: Contribution to journalArticlepeer-review

Abstract

The authors report their experience on the chemoprevention of colorectal cancer with COX2 inhibitors. The people were selected by means of rectal biopsy in order to identify those with histologic precancerous mucosal lesions (increased proliferation of cryptic colonic epithelial cells). In point of fact, neoplastic lesions develop in a limited area of the colon-rectum, but the entire large bowel may be at risk for tumoural growth, so the rectal mucosa is suitable for the screening of hyperproliferative mucosal status. Preliminary results offer encouraging evidence that the premalignant epithelial proliferation can be reversed by the administration of COX2 inhibitors, but only long-term, randomised, clinical trials will be able to confirm the rôle of this treatment for colorectal cancer chemoprevention.

Translated title of the contributionNew prospects in the prevention of colorectal cancer: The screening for precancerous lesions by rectal biopsy and chemoprevention with COX2 inhibitors
Original languageItalian
Pages (from-to)103-106
Number of pages4
JournalEuropean Journal of Oncology
Volume9
Issue number2
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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