The authors report their experience on the chemoprevention of colorectal cancer with COX2 inhibitors. The people were selected by means of rectal biopsy in order to identify those with histologic precancerous mucosal lesions (increased proliferation of cryptic colonic epithelial cells). In point of fact, neoplastic lesions develop in a limited area of the colon-rectum, but the entire large bowel may be at risk for tumoural growth, so the rectal mucosa is suitable for the screening of hyperproliferative mucosal status. Preliminary results offer encouraging evidence that the premalignant epithelial proliferation can be reversed by the administration of COX2 inhibitors, but only long-term, randomised, clinical trials will be able to confirm the rôle of this treatment for colorectal cancer chemoprevention.
|Translated title of the contribution||New prospects in the prevention of colorectal cancer: The screening for precancerous lesions by rectal biopsy and chemoprevention with COX2 inhibitors|
|Number of pages||4|
|Journal||European Journal of Oncology|
|Publication status||Published - Oct 2004|
ASJC Scopus subject areas
- Cancer Research