New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia

Salvatore Siena, Gabriella Sammarelli, Maria Grazia Grimoldi, Roberta Schiavo, Andrea Nozza, Massimo Roncalli, Cristina Mecucci, Armando Santoro, Carmelo Carlo-Stella

Research output: Contribution to journalArticle

Abstract

We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products includIng benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU- E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T- lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalHaematologica
Volume84
Issue number4
Publication statusPublished - Apr 1999

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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Granulocyte-Macrophage Progenitor Cells
Erythroid Precursor Cells
Myeloproliferative Disorders
Genetic Translocation
Cytogenetic Analysis
Petroleum
Occupational Exposure
Metaphase
Hydrocarbons
Benzene
Karyotype
Granulocytes
Bone Marrow Cells
Fibroblasts
Macrophages
T-Lymphocytes
Skin
Genes

Keywords

  • Atypical chronic myeloid leukemia
  • Chromosomal translocation t(5;10)(q33;q22)

ASJC Scopus subject areas

  • Hematology

Cite this

New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia. / Siena, Salvatore; Sammarelli, Gabriella; Grimoldi, Maria Grazia; Schiavo, Roberta; Nozza, Andrea; Roncalli, Massimo; Mecucci, Cristina; Santoro, Armando; Carlo-Stella, Carmelo.

In: Haematologica, Vol. 84, No. 4, 04.1999, p. 369-372.

Research output: Contribution to journalArticle

Siena, Salvatore ; Sammarelli, Gabriella ; Grimoldi, Maria Grazia ; Schiavo, Roberta ; Nozza, Andrea ; Roncalli, Massimo ; Mecucci, Cristina ; Santoro, Armando ; Carlo-Stella, Carmelo. / New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia. In: Haematologica. 1999 ; Vol. 84, No. 4. pp. 369-372.
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AU - Sammarelli, Gabriella

AU - Grimoldi, Maria Grazia

AU - Schiavo, Roberta

AU - Nozza, Andrea

AU - Roncalli, Massimo

AU - Mecucci, Cristina

AU - Santoro, Armando

AU - Carlo-Stella, Carmelo

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N2 - We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products includIng benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU- E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T- lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.

AB - We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products includIng benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU- E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T- lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.

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