New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia

Salvatore Siena, Gabriella Sammarelli, Maria Grazia Grimoldi, Roberta Schiavo, Andrea Nozza, Massimo Roncalli, Cristina Mecucci, Armando Santoro, Carmelo Carlo-Stella

Research output: Contribution to journalArticle

Abstract

We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products includIng benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU- E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T- lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalHaematologica
Volume84
Issue number4
Publication statusPublished - Apr 1999

Keywords

  • Atypical chronic myeloid leukemia
  • Chromosomal translocation t(5;10)(q33;q22)

ASJC Scopus subject areas

  • Hematology

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