New recurrent chromosome change in pediatric therapy-related myelodysplastic syndrome: Unbalanced translocation 1/6 with cryptic duplication of short arm of chromosome 6

Elisa Tassano, Elisa Tavella, Roberto Valli, Concetta Micalizzi, Cristina Cuoco, Emanuela Maserati, Francesco Pasquali, Cristina Morerio

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence of therapy-related myelodysplastic syndrome (t-MDS) in pediatric patients is increasing in parallel with the more successful management of the primary tumor, but scant information is available on clinical and cytogenetic characteristics. We report here two children affected by t-MDS after chemo/radiotherapy for a primary solid tumor, both with an unbalanced translocation 1/6 in their bone marrow. Characterization by array comparative genomic hybridization of the imbalances showed an almost identical pattern: almost complete trisomy of the long arm of chromosome 1, and a terminal deletion and interstitial duplication of the short arm of chromosome 6. The gain of chromosome 6 short arm encompasses regions already highlighted as possibly relevant for t-MDS in adults, and we suggest that the unbalanced translocation reported here be considered a new recurrent, non-random chromosomal abnormality in pediatric patients with t-MDS.

Original languageEnglish
Pages (from-to)2434-2438
Number of pages5
JournalLeukemia and Lymphoma
Volume53
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Array-CGH
  • Pediatric age
  • T-MDS
  • Unbalanced translocation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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