TY - JOUR
T1 - New recurrent chromosome change in pediatric therapy-related myelodysplastic syndrome
T2 - Unbalanced translocation 1/6 with cryptic duplication of short arm of chromosome 6
AU - Tassano, Elisa
AU - Tavella, Elisa
AU - Valli, Roberto
AU - Micalizzi, Concetta
AU - Cuoco, Cristina
AU - Maserati, Emanuela
AU - Pasquali, Francesco
AU - Morerio, Cristina
PY - 2012/12
Y1 - 2012/12
N2 - The incidence of therapy-related myelodysplastic syndrome (t-MDS) in pediatric patients is increasing in parallel with the more successful management of the primary tumor, but scant information is available on clinical and cytogenetic characteristics. We report here two children affected by t-MDS after chemo/radiotherapy for a primary solid tumor, both with an unbalanced translocation 1/6 in their bone marrow. Characterization by array comparative genomic hybridization of the imbalances showed an almost identical pattern: almost complete trisomy of the long arm of chromosome 1, and a terminal deletion and interstitial duplication of the short arm of chromosome 6. The gain of chromosome 6 short arm encompasses regions already highlighted as possibly relevant for t-MDS in adults, and we suggest that the unbalanced translocation reported here be considered a new recurrent, non-random chromosomal abnormality in pediatric patients with t-MDS.
AB - The incidence of therapy-related myelodysplastic syndrome (t-MDS) in pediatric patients is increasing in parallel with the more successful management of the primary tumor, but scant information is available on clinical and cytogenetic characteristics. We report here two children affected by t-MDS after chemo/radiotherapy for a primary solid tumor, both with an unbalanced translocation 1/6 in their bone marrow. Characterization by array comparative genomic hybridization of the imbalances showed an almost identical pattern: almost complete trisomy of the long arm of chromosome 1, and a terminal deletion and interstitial duplication of the short arm of chromosome 6. The gain of chromosome 6 short arm encompasses regions already highlighted as possibly relevant for t-MDS in adults, and we suggest that the unbalanced translocation reported here be considered a new recurrent, non-random chromosomal abnormality in pediatric patients with t-MDS.
KW - Array-CGH
KW - Pediatric age
KW - T-MDS
KW - Unbalanced translocation
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U2 - 10.3109/10428194.2012.695778
DO - 10.3109/10428194.2012.695778
M3 - Article
C2 - 22616618
AN - SCOPUS:84868351295
VL - 53
SP - 2434
EP - 2438
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 12
ER -