New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.

M. Devoto, L. De Benedetti, P. Ronchetto, L. Romano, G. Romeo, L. C. Tsui, M. Dean, F. Collins, M. Seia, L. Piceni Sereni

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Abstract

We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.

Original languageEnglish
Pages (from-to)102-104
Number of pages3
JournalActa Universitatis Carolinae Medica
Volume36
Issue number1-4
Publication statusPublished - 1990

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Linkage Disequilibrium
Restriction Fragment Length Polymorphisms
Exocrine Pancreatic Insufficiency
Haplotypes
Alleles
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Devoto, M., De Benedetti, L., Ronchetto, P., Romano, L., Romeo, G., Tsui, L. C., ... Piceni Sereni, L. (1990). New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients. Acta Universitatis Carolinae Medica, 36(1-4), 102-104.

New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients. / Devoto, M.; De Benedetti, L.; Ronchetto, P.; Romano, L.; Romeo, G.; Tsui, L. C.; Dean, M.; Collins, F.; Seia, M.; Piceni Sereni, L.

In: Acta Universitatis Carolinae Medica, Vol. 36, No. 1-4, 1990, p. 102-104.

Research output: Contribution to journalArticle

Devoto, M, De Benedetti, L, Ronchetto, P, Romano, L, Romeo, G, Tsui, LC, Dean, M, Collins, F, Seia, M & Piceni Sereni, L 1990, 'New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.', Acta Universitatis Carolinae Medica, vol. 36, no. 1-4, pp. 102-104.
Devoto, M. ; De Benedetti, L. ; Ronchetto, P. ; Romano, L. ; Romeo, G. ; Tsui, L. C. ; Dean, M. ; Collins, F. ; Seia, M. ; Piceni Sereni, L. / New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients. In: Acta Universitatis Carolinae Medica. 1990 ; Vol. 36, No. 1-4. pp. 102-104.
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