New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.

M. Devoto, L. De Benedetti, P. Ronchetto, L. Romano, G. Romeo, L. C. Tsui, M. Dean, F. Collins, M. Seia, L. Piceni Sereni

Research output: Contribution to journalArticlepeer-review

Abstract

We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.

Original languageEnglish
Pages (from-to)102-104
Number of pages3
JournalActa Universitatis Carolinae Medica
Volume36
Issue number1-4
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Medicine(all)

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