New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.

M. Devoto; L. De Benedetti; P. Ronchetto; L. Romano; G. Romeo; L. C. Tsui; M. Dean; F. Collins; M. Seia; L. Piceni Sereni

New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.

M. Devoto, L. De Benedetti, P. Ronchetto, L. Romano, G. Romeo, L. C. Tsui, M. Dean, F. Collins, M. Seia, L. Piceni Sereni

Research output: Contribution to journal › Article › peer-review

Abstract

We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.

Original language	English
Pages (from-to)	102-104
Number of pages	3
Journal	Acta Universitatis Carolinae Medica
Volume	36
Issue number	1-4
Publication status	Published - 1990

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.",

abstract = "We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.",

author = "M. Devoto and {De Benedetti}, L. and P. Ronchetto and L. Romano and G. Romeo and Tsui, {L. C.} and M. Dean and F. Collins and M. Seia and {Piceni Sereni}, L.",

year = "1990",

language = "English",

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T1 - New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.

AU - Devoto, M.

AU - De Benedetti, L.

AU - Ronchetto, P.

AU - Romano, L.

AU - Romeo, G.

AU - Tsui, L. C.

AU - Dean, M.

AU - Collins, F.

AU - Seia, M.

AU - Piceni Sereni, L.

PY - 1990

Y1 - 1990

N2 - We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.

AB - We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.

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ER -

New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.

Abstract

ASJC Scopus subject areas

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