New scenarios in secondary hyperparathyroidism: etelcalcetide. Position paper of working group on CKD-MBD of the Italian Society of Nephrology: Journal of Nephrology

A. Bellasi, M. Cozzolino, F. Malberti, G. Cancarini, C. Esposito, C.M. Guastoni, P. Ondei, G. Pontoriero, U. Teatini, G. Vezzoli, M. Pasquali, P. Messa, F. Locatelli

Research output: Contribution to journalArticlepeer-review

Abstract

Bone mineral abnormalities (defined as Chronic Kidney Disease Mineral Bone Disorder; CKD-MBD) are prevalent and associated with a substantial risk burden and poor prognosis in CKD population. Several lines of evidence support the notion that a large proportion of patients receiving maintenance dialysis experience a suboptimal biochemical control of CKD-MBD. Although no study has ever demonstrated conclusively that CKD-MBD control is associated with improved survival, an expanding therapeutic armamentarium is available to correct bone mineral abnormalities. In this position paper of Lombardy Nephrologists, a summary of the state of art of CKD-MBD as well as a summary of the unmet clinical needs will be provided. Furthermore, this position paper will focus on the potential and drawbacks of a new injectable calcimimetic, etelcalcetide, a drug available in Italy since few months ago. © 2019, The Author(s).
Original languageEnglish
Pages (from-to)211-221
Number of pages11
JournalJ. Nephrol.
Volume33
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Cinacalcet
  • CKD-MBD
  • Etelcalcetide
  • PTH
  • Secondary hyperparathyroidism
  • calcium
  • cinacalcet
  • etelcalcetide
  • fibroblast growth factor 23
  • parathyroid hormone
  • phosphate
  • vitamin D
  • Article
  • bone mineralization
  • chronic kidney disease-mineral and bone disorder
  • diarrhea
  • heart valve calcification
  • human
  • hypocalcemia
  • hypokalemia
  • hypotension
  • long QT syndrome
  • muscle spasm
  • nausea
  • nonhuman
  • paresthesia
  • secondary hyperparathyroidism
  • sudden cardiac death
  • vomiting

Fingerprint

Dive into the research topics of 'New scenarios in secondary hyperparathyroidism: etelcalcetide. Position paper of working group on CKD-MBD of the Italian Society of Nephrology: Journal of Nephrology'. Together they form a unique fingerprint.

Cite this