New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts

Aldo Pagano, Manuele Castelnuovo, Federico Tortelli, Roberto Ferrari, Giorgio Dieci, Ranieri Cancedda

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.

Original languageEnglish
Pages (from-to)174-184
Number of pages11
JournalPLoS Genetics
Volume3
Issue number2
DOIs
Publication statusPublished - Feb 2007

Fingerprint

small nuclear RNA
Small Nuclear RNA
Untranslated RNA
Gene Regulatory Networks
Human Genome
Transcriptome
RNA
gene
Genes
Proteins
genes
homology
transcriptome
genome
transcription (genetics)
promoter regions
protein
proteins

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts. / Pagano, Aldo; Castelnuovo, Manuele; Tortelli, Federico; Ferrari, Roberto; Dieci, Giorgio; Cancedda, Ranieri.

In: PLoS Genetics, Vol. 3, No. 2, 02.2007, p. 174-184.

Research output: Contribution to journalArticle

Pagano, A, Castelnuovo, M, Tortelli, F, Ferrari, R, Dieci, G & Cancedda, R 2007, 'New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts', PLoS Genetics, vol. 3, no. 2, pp. 174-184. https://doi.org/10.1371/journal.pgen.0030001
Pagano, Aldo ; Castelnuovo, Manuele ; Tortelli, Federico ; Ferrari, Roberto ; Dieci, Giorgio ; Cancedda, Ranieri. / New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts. In: PLoS Genetics. 2007 ; Vol. 3, No. 2. pp. 174-184.
@article{5019a53111144ce6bffbe3712470a257,
title = "New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts",
abstract = "By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.",
author = "Aldo Pagano and Manuele Castelnuovo and Federico Tortelli and Roberto Ferrari and Giorgio Dieci and Ranieri Cancedda",
year = "2007",
month = "2",
doi = "10.1371/journal.pgen.0030001",
language = "English",
volume = "3",
pages = "174--184",
journal = "PLoS Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts

AU - Pagano, Aldo

AU - Castelnuovo, Manuele

AU - Tortelli, Federico

AU - Ferrari, Roberto

AU - Dieci, Giorgio

AU - Cancedda, Ranieri

PY - 2007/2

Y1 - 2007/2

N2 - By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.

AB - By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.

UR - http://www.scopus.com/inward/record.url?scp=33847251953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847251953&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.0030001

DO - 10.1371/journal.pgen.0030001

M3 - Article

C2 - 17274687

AN - SCOPUS:33847251953

VL - 3

SP - 174

EP - 184

JO - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7390

IS - 2

ER -