New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts

Aldo Pagano, Manuele Castelnuovo, Federico Tortelli, Roberto Ferrari, Giorgio Dieci, Ranieri Cancedda

Research output: Contribution to journalArticle

Abstract

By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.

Original languageEnglish
Pages (from-to)174-184
Number of pages11
JournalPLoS Genetics
Volume3
Issue number2
DOIs
Publication statusPublished - Feb 2007

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts'. Together they form a unique fingerprint.

  • Cite this