New strategies for treatment of Candida vaginal infections

Walter Magliani, Stefania Conti, Antonella Salati, Simona Arseni, Raffaele Frazzi, Lara Ravanetti, Luciano Polonelli

Research output: Contribution to journalArticlepeer-review

Abstract

New strategies for treatment of vaginal candidiasis have been recently exploited, due to widespread occurrence of this disease, in particular as recurrent infections, limitations of safe and efficacious antifungals as well as the lack of reliable preventative approaches. In this review new chemotherapeutic and immunotherapeutic strategies, based on the improved understanding of the immunopathogenesis of this prevalent human infection, will be discussed. The role of killer antibodies (or their molecular derivatives), i.e. antibodies that show antibiotic activity bearing the internal image of a yeast killer toxin (KT), characterized by a wide spectrum of microbicidal activity, and of the specific cell wall KT receptor as putative new therapeutic agents and preventative or therapeutic vaccines, respectively, will be particularly outlined.

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalRevista Iberoamericana de Micologia
Volume19
Issue number3
Publication statusPublished - Sep 2002

Keywords

  • Anticandidal chemotherapy
  • Anticandidal immunotherapy
  • Anticandidal vaccines
  • Killer antibodies
  • Vaginal candidiasis

ASJC Scopus subject areas

  • Microbiology

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