New targets in the search for preventive and therapeutic agents for botulism

Fabrizio Anniballi, Davide Lonati, Alfonsina Fiore, Bruna Auricchio, Dario De Medici, Carlo Alessandro Locatelli

Research output: Contribution to journalArticle

Abstract

Botulism is a severe neuroparalytic disease resulting from exposure to one of the most poisonous toxins to humans. Because of this high potency and the use of toxins as biological weapons, botulism is a public health concern and each case represents an emergency. Current therapy involves respiratory supportive care and anti-toxins administration. As a preventive measure, vaccination against toxins represents an effective strategy but is undesirable due the rarity of botulism and the effectiveness of toxins in treating several neuromuscular disorders. This paper summarizes the current issues in botulism treatment and prevention, highlighting the challenge for future researches.

Original languageEnglish
Pages (from-to)1075-1086
Number of pages12
JournalExpert Review of Anti-Infective Therapy
Volume12
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • bacteriocins
  • botulinum toxin
  • botulism
  • inhibitors
  • microbial antagonism
  • prevention
  • therapy
  • vaccine

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology
  • Medicine(all)

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