New targets of neuroprotection in ischemic stroke

Marco Bacigaluppi, Dirk M. Hermann

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ischemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is intravenous or intra-arterial thrombolysis that is limited to the very first hours after the stroke. Starting with recent findings about the pathophysiology of stroke and presenting an overview on current experimental models of this clinically highly relevant neurological disease, this paper will provide an overview on existing and emerging treatment concepts in ischemic stroke. Thus, our review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts. In the last section of our paper, we will examine more closely how experimental data are presently translated to humans, with particular emphasis on the bioaccumulation and efficacy of drugs. From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established.

Original languageEnglish
Pages (from-to)698-712
Number of pages15
JournalTheScientificWorldJournal
Volume8
DOIs
Publication statusPublished - Jul 13 2008

Fingerprint

Stroke
Bioaccumulation
Neurology
neurology
Pharmaceutical Preparations
bioaccumulation
Neuroprotection
drug
Theoretical Models
Pharmacology
damage
Therapeutics

Keywords

  • Animal models
  • Neuroprotection
  • Neurorestoration
  • Pathophysiology
  • Reperfusion
  • Stroke

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

New targets of neuroprotection in ischemic stroke. / Bacigaluppi, Marco; Hermann, Dirk M.

In: TheScientificWorldJournal, Vol. 8, 13.07.2008, p. 698-712.

Research output: Contribution to journalArticle

@article{04a67faacb4c4489a1a84ed5ef7b3255,
title = "New targets of neuroprotection in ischemic stroke",
abstract = "Ischemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is intravenous or intra-arterial thrombolysis that is limited to the very first hours after the stroke. Starting with recent findings about the pathophysiology of stroke and presenting an overview on current experimental models of this clinically highly relevant neurological disease, this paper will provide an overview on existing and emerging treatment concepts in ischemic stroke. Thus, our review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts. In the last section of our paper, we will examine more closely how experimental data are presently translated to humans, with particular emphasis on the bioaccumulation and efficacy of drugs. From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established.",
keywords = "Animal models, Neuroprotection, Neurorestoration, Pathophysiology, Reperfusion, Stroke",
author = "Marco Bacigaluppi and Hermann, {Dirk M.}",
year = "2008",
month = "7",
day = "13",
doi = "10.1100/tsw.2008.94",
language = "English",
volume = "8",
pages = "698--712",
journal = "The Scientific World Journal",
issn = "2356-6140",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - New targets of neuroprotection in ischemic stroke

AU - Bacigaluppi, Marco

AU - Hermann, Dirk M.

PY - 2008/7/13

Y1 - 2008/7/13

N2 - Ischemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is intravenous or intra-arterial thrombolysis that is limited to the very first hours after the stroke. Starting with recent findings about the pathophysiology of stroke and presenting an overview on current experimental models of this clinically highly relevant neurological disease, this paper will provide an overview on existing and emerging treatment concepts in ischemic stroke. Thus, our review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts. In the last section of our paper, we will examine more closely how experimental data are presently translated to humans, with particular emphasis on the bioaccumulation and efficacy of drugs. From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established.

AB - Ischemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is intravenous or intra-arterial thrombolysis that is limited to the very first hours after the stroke. Starting with recent findings about the pathophysiology of stroke and presenting an overview on current experimental models of this clinically highly relevant neurological disease, this paper will provide an overview on existing and emerging treatment concepts in ischemic stroke. Thus, our review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts. In the last section of our paper, we will examine more closely how experimental data are presently translated to humans, with particular emphasis on the bioaccumulation and efficacy of drugs. From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established.

KW - Animal models

KW - Neuroprotection

KW - Neurorestoration

KW - Pathophysiology

KW - Reperfusion

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=47349088595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47349088595&partnerID=8YFLogxK

U2 - 10.1100/tsw.2008.94

DO - 10.1100/tsw.2008.94

M3 - Article

C2 - 18661057

AN - SCOPUS:47349088595

VL - 8

SP - 698

EP - 712

JO - The Scientific World Journal

JF - The Scientific World Journal

SN - 2356-6140

ER -