New techniques for sentinel node biopsy in breast cancer

Massimo Ferrucci, Gianluca Franceschini, Michael Douek

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Sentinel lymph node biopsy (SLNB) is still the standard of care for axillary nodal staging in patients with invasive breast cancer (BC) and clinically negative lymph nodes (LNs). It successfully replaced the more invasive and morbid axillary lymph node dissection (ALND). The actual standard for SLNB is the radioisotope (RI) with or without blue dye (BD) technique. Because of several drawbacks reported in worldwide experiences, new techniques have been developed in the last years: indocyanine green (ICG) fluorescence, superparamagnetic iron oxide (SPIO) nanoparticles and contrast-enhanced ultrasound (CEUS) using microbubbles. Whilst each technique has its own advantages/disadvantages they are increasing their efficacy and are candidate to represent a new standard for SLNB in next future. This is a comprehensive review of current limitations of conventional techniques besides the improvements and innovations of new methods which, anyway, need future randomized controlled trials to be fully validated.

Original languageEnglish
Pages (from-to)S405-S417
JournalTranslational Cancer Research
Volume7
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Sentinel Lymph Node Biopsy
Breast Neoplasms
Biopsy
Microbubbles
Indocyanine Green
Standard of Care
Lymph Node Excision
Radioisotopes
Nanoparticles
Coloring Agents
Randomized Controlled Trials
Fluorescence
Lymph Nodes
cyhalothrin

Keywords

  • Breast cancer (BC)
  • Indocyanine green (ICG)
  • Microbubble
  • Sentinel node biopsy
  • Superparamagnetic iron oxyde

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

New techniques for sentinel node biopsy in breast cancer. / Ferrucci, Massimo; Franceschini, Gianluca; Douek, Michael.

In: Translational Cancer Research, Vol. 7, 01.04.2018, p. S405-S417.

Research output: Contribution to journalReview article

Ferrucci, Massimo ; Franceschini, Gianluca ; Douek, Michael. / New techniques for sentinel node biopsy in breast cancer. In: Translational Cancer Research. 2018 ; Vol. 7. pp. S405-S417.
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