New therapies in SLE

Francesca Ferrera; Gilberto Filaci; Marta Rizzi; Ram P. Singh; Francesco Indiveri; Bevra H. Hahn; Antonio La Cava

doi:10.2174/187221308783399243

New therapies in SLE

Francesca Ferrera, Gilberto Filaci, Marta Rizzi, Ram P. Singh, Francesco Indiveri, Bevra H. Hahn, Antonio La Cava

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The therapy of systemic lupus erythematosus (SLE), a systemic autoimmune disease of unknown aetiology, is significantly complicated by the diversity of disease manifestations and by a variety of complex immune abnormalities. Recent preclinical studies have shown the therapeutic efficacy of several. drugs and/or new compounds, some of which have been tested in clinical trials. This review provides an update on the use of new approaches in SLE and recent patents that could develop into novel therapeutics available to the clinical armamentarium for the management of the disease.

Original language	English
Pages (from-to)	11-23
Number of pages	13
Journal	Recent Patents on Inflammation and Allergy Drug Discovery
Volume	2
Issue number	1
DOIs	https://doi.org/10.2174/187221308783399243
Publication status	Published - Jan 2008

Keywords

β cells
Autoimmune disease
Costimulation
Immune tolerance
Systemic lupus erythematosus
Therapy

ASJC Scopus subject areas

Drug Discovery
Immunology and Allergy

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10.2174/187221308783399243

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abstract = "The therapy of systemic lupus erythematosus (SLE), a systemic autoimmune disease of unknown aetiology, is significantly complicated by the diversity of disease manifestations and by a variety of complex immune abnormalities. Recent preclinical studies have shown the therapeutic efficacy of several. drugs and/or new compounds, some of which have been tested in clinical trials. This review provides an update on the use of new approaches in SLE and recent patents that could develop into novel therapeutics available to the clinical armamentarium for the management of the disease.",

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AU - Hahn, Bevra H.

AU - La Cava, Antonio

PY - 2008/1

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AB - The therapy of systemic lupus erythematosus (SLE), a systemic autoimmune disease of unknown aetiology, is significantly complicated by the diversity of disease manifestations and by a variety of complex immune abnormalities. Recent preclinical studies have shown the therapeutic efficacy of several. drugs and/or new compounds, some of which have been tested in clinical trials. This review provides an update on the use of new approaches in SLE and recent patents that could develop into novel therapeutics available to the clinical armamentarium for the management of the disease.

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KW - Costimulation

KW - Immune tolerance

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New therapies in SLE

Abstract

Keywords

ASJC Scopus subject areas

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