New therapy for orolaryngeal manifestations of Crohn's disease

Francesco Ottaviani, Antonio Schindler, Mara Petrone, Pasquale Capaccio, Gabriele Bianchi Porro

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Crohn's disease is a chronic inflammation that may involve the entire gastrointestinal tract, from the mouth to the anus. The most widely accepted etiologic theory involves an immunologic aberration leading to local tissue destruction. Cell-mediated immunity with increased tumor necrosis factor (TNF) production may play a role in mucosal damage. Oral and laryngeal involvement are rare manifestations of Crohn's disease that are usually treated successfully by steroids. We here report a rare case of extra-intestinal Crohn's disease resistant to steroid therapy, which was successfully treated with infliximab, a chimeric antibody directed against TNF-α that is the only registered agent for the treatment of Crohn's disease. The relative safety, efficacy, and efficiency of infliximab make it an alternative treatment of which otolaryngologists should be aware.

Original languageEnglish
Pages (from-to)37-39
Number of pages3
JournalAnnals of Otology, Rhinology and Laryngology
Volume112
Issue number1
Publication statusPublished - Jan 1 2003

Fingerprint

Crohn Disease
Tumor Necrosis Factor-alpha
Steroids
Intestinal Diseases
Anal Canal
Therapeutics
Cellular Immunity
Mouth
Gastrointestinal Tract
Inflammation
Safety
Antibodies
Infliximab

Keywords

  • Crohn's disease
  • Infliximab
  • Larynx
  • Oral cavity

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Ottaviani, F., Schindler, A., Petrone, M., Capaccio, P., & Porro, G. B. (2003). New therapy for orolaryngeal manifestations of Crohn's disease. Annals of Otology, Rhinology and Laryngology, 112(1), 37-39.

New therapy for orolaryngeal manifestations of Crohn's disease. / Ottaviani, Francesco; Schindler, Antonio; Petrone, Mara; Capaccio, Pasquale; Porro, Gabriele Bianchi.

In: Annals of Otology, Rhinology and Laryngology, Vol. 112, No. 1, 01.01.2003, p. 37-39.

Research output: Contribution to journalArticle

Ottaviani, F, Schindler, A, Petrone, M, Capaccio, P & Porro, GB 2003, 'New therapy for orolaryngeal manifestations of Crohn's disease', Annals of Otology, Rhinology and Laryngology, vol. 112, no. 1, pp. 37-39.
Ottaviani, Francesco ; Schindler, Antonio ; Petrone, Mara ; Capaccio, Pasquale ; Porro, Gabriele Bianchi. / New therapy for orolaryngeal manifestations of Crohn's disease. In: Annals of Otology, Rhinology and Laryngology. 2003 ; Vol. 112, No. 1. pp. 37-39.
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