New therapy for orolaryngeal manifestations of Crohn's disease

Francesco Ottaviani, Antonio Schindler, Mara Petrone, Pasquale Capaccio, Gabriele Bianchi Porro

Research output: Contribution to journalArticlepeer-review

Abstract

Crohn's disease is a chronic inflammation that may involve the entire gastrointestinal tract, from the mouth to the anus. The most widely accepted etiologic theory involves an immunologic aberration leading to local tissue destruction. Cell-mediated immunity with increased tumor necrosis factor (TNF) production may play a role in mucosal damage. Oral and laryngeal involvement are rare manifestations of Crohn's disease that are usually treated successfully by steroids. We here report a rare case of extra-intestinal Crohn's disease resistant to steroid therapy, which was successfully treated with infliximab, a chimeric antibody directed against TNF-α that is the only registered agent for the treatment of Crohn's disease. The relative safety, efficacy, and efficiency of infliximab make it an alternative treatment of which otolaryngologists should be aware.

Original languageEnglish
Pages (from-to)37-39
Number of pages3
JournalAnnals of Otology, Rhinology and Laryngology
Volume112
Issue number1
Publication statusPublished - Jan 1 2003

Keywords

  • Crohn's disease
  • Infliximab
  • Larynx
  • Oral cavity

ASJC Scopus subject areas

  • Otorhinolaryngology

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